Objectives and methods:
The aims of the present work were to assess the presence of thrombin generation in Crohn's disease and in ulcerative colitis by using the prothrombin fragment 1+2 and the thrombin–antithrombin III complex assays and to study the possible relationships between these markers and disease activity.
Prothrombin fragment 1+2 and thrombin–antithrombin III complex were significantly raised in patients with Crohn's disease (n=69) and with ulcerative colitis (n=25) as compared with healthy controls (n=50). In Crohn's disease these two markers of thrombin generation were correlated with the Van Hees index (P<0.05 and P<0.001, respectively); values were significantly different from controls even in the patient group displaying the lowest disease activity (P<0.001). No correlation was found with tumour necrosis factor α and C-reactive protein; nevertheless patients with C-reactive protein less than or equal to 10 mg/l had significant lower values of prothrombin fragment 1+2 (P<0.03). In ulcerative colitis prothrombin fragment 1+2 and thrombin–antithrombin III complex were significantly increased by comparison with controls, were higher in patients with pancolitis and correlated with C-reactive protein (P<0.002 and P<0.009, respectively).
These data show that prothrombin fragment 1+2 and thrombin–antithrombin III complex are increased in inflammatory bowel diseases and suggest that thrombin generation might be an early event in their pathogenesis.
European Journal of Gastroenterology & Hepatology 1995, 7:1183–1188
© Lippincott-Raven Publishers.