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Quick Sepsis-related Organ Failure Assessment predicts 72-h mortality in patients with suspected infection

Chen, Fu-Chenga; Kung, Chia-Tea; Cheng, Hsien-Hunga; Cheng, Chi-Yunga; Tsai, Tsung-Chenga; Hsiao, Sheng-Yuana; Su, Chih-Mina,b

European Journal of Emergency Medicine: July 25, 2018 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MEJ.0000000000000563
Original article: PDF Only

Objective The aim of this study was to compare quick Sepsis-related Organ Failure Assessment (qSOFA) and Systemic Inflammatory Response Syndrome (SIRS) scores for predicting mortality.

Patients and methods A single-center, retrospective study of adult patients with suspected infection was conducted. Area under the curve (AUC) and multivariate analyses were used to explore associations between the qSOFA and SIRS scores and mortality.

Results Of the 69 115 patients enrolled, 1798 died within 72 h and 5640 within 28 days. The qSOFA scores were better than SIRS scores at predicting 72-h mortality (AUC: 0.77 vs. 0.64). However, the discriminatory power of both scores was low in terms of 28-day mortality (AUC: 0.69 vs. 0.60). Patients with qSOFA score of at least 2 had a higher hazard ratio for 72-h mortality than for 28-day mortality (2.64 vs. 1.91).

Conclusion The qSOFA scores are more accurate than SIRS scores for predicting 72-h mortality and are better at predicting 72-h mortality than 28-day mortality.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

aDepartment of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung

bSchool of Medicine, Chung Shan Medical University, Taichung, Taiwan

Correspondence to Chih-Min Su, MD, PhD, Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123 Ta Pei Road, Niaosong District, Kaohsiung 833, Taiwan Tel: +886 77 317 123 x8415; fax: +886 7735 3815; e-mails:,

Received January 22, 2018

Accepted May 21, 2018

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