SHORT REPORTSLactate is associated with increased 10-day mortality in acute medical patients a hospital-based cohort studyHaidl, Felixa; Brabrand, Mikkelc; Henriksen, Daniel P.b; Lassen, Annmarie T.bAuthor Information aDepartment of Anesthesia, Lillebaelt Hospital, Kolding bDepartment of Emergency Medicine, Odense University Hospital, Odense cDepartment of Emergency Medicine, Hospital of South West Jutland, Esbjerg, Denmark Correspondence to Felix Haidl, MD, Department of Anesthesia, Lillebaelt Hospital, Skovvangen 2, DK-6000 Kolding, Denmark Tel: +47 46 65 67 07; fax: +47 67 96 88 61; e-mail: [email protected] Received March 23, 2014 Accepted August 21, 2014 European Journal of Emergency Medicine: August 2015 - Volume 22 - Issue 4 - p 282-284 doi: 10.1097/MEJ.0000000000000210 Buy Metrics Abstract An increased lactate level is related to increased mortality in subpopulations of critically ill patients. The aim of this study was to investigate whether lactate was related to mortality in an emergency department (ED) setting of undifferentiated medical patients. All adult patients admitted from March 2009 to August 2011 to a medical ED with lactate measured within 6 h after arrival were studied. Lactate was stratified into 1-mmol/l intervals and analysed in a multivariate logistic regression analysis. A total of 5317 patients were included, 46.9% men, median age 71 years (5–95% percentiles 25–90 years). The median lactate level was 1.2 mmol/l (5–95% percentiles 0.6–3.8 mmol/l, range 0.2–22 mmol/l). Lactate was associated with 10-day mortality independent of age, comorbidity and presence of hypotension, with an odds ratio of 1.54 (95% confidence interval 1.44–1.63) per 1 mmol/l increase. Lactate is an independent predictor of 10-day mortality among patients admitted to a medical ED. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.