Research papers: Lifestyle FactorsParental smoking, maternal alcohol, coffee and tea consumption during pregnancy and childhood malignant central nervous system tumours: the ESCALE study (SFCE)*Plichart, Matthieua b; Menegaux, Florencea b; Lacour, Brigittea b d; Hartmann, Olivierc; Frappaz, Didierf; Doz, Françoisg; Bertozzi, Anne-Isabelleh; Defaschelles, Anne-Sophiei; Pierre-Kahn, Alainj; Icher, Célinek; Chastagner, Pascale; Plantaz, Dominiquel; Rialland, Xavierm; Hémon, Denisa b; Clavel, Jacquelinea b nAuthor Information aINSERM, U754, Villejuif bUniv Paris-Sud, UMR-S754, IFR69, Villejuif cGustave Roussy, Institute, Villejuif dFrench National Registry of Childhood Solid Tumours, Nancy eChildren's Hospital, Vandoeuvre les Nancy fLéon Bérard Centre, Lyon gCurie Institute, Paris hChildren's Hospital, Toulouse iOscar Lambret Centre, Lille jChildren's Hospital of Necker, Paris kPellegrin Tripode Hospital, Bordeaux lPaediatric Department, Grenoble mAngers Hospital, Angers nFrench National Registry of Childhood Haematopoietic Malignancies, France Correspondence to Dr Florence Menegaux, MD, PhD, INSERM U754, 16, av. Paul Vaillant-Couturier, Villejuif Cedex F-94807, France Tel: +33 1 45 59 51 53; fax: +33 1 45 59 51 91; e-mail: [email protected] *SFCE: Société Française de lutte contre les Cancers de l'Enfant et de l'Adolescent. Received 26 March 2007 Accepted 30 August 2007 European Journal of Cancer Prevention: August 2008 - Volume 17 - Issue 4 - p 376-383 doi: 10.1097/CEJ.0b013e3282f75e6f Buy Metrics Abstract Parental smoking and maternal alcohol and caffeinated beverage consumption are prevalent exposures which may play a role, either directly or through their influence on metabolism, in the aetiology of childhood malignant central nervous system (CNS) tumours. The hypothesis was investigated in the Epidemiological Study on childhood Cancer and Leukemia ESCALE study, a national population-based case–control study carried out in France in 2003–2004. The study included 209 incident cases of CNS tumours and 1681 population-based controls, frequency matched with the cases by age and sex. The data were collected through a standardized telephone interview of the biological mothers. No association between maternal smoking during pregnancy and CNS tumours [odds ratio (OR): 1.1 (0.8–1.6)] was observed. Paternal smoking during the year before birth was associated with CNS tumours (P for trend=0.04), particularly astrocytomas [OR: 3.1 (1.3–7.6)]. Maternal alcohol consumption during pregnancy was not associated with CNS tumours. Associations between ependymomas and the highest consumption of coffee [OR: 2.7 (0.9–8.1)] and tea [OR: 2.5 (1.1–5.9)] were observed. A strong association between CNS tumours and the highest maternal consumption of both coffee and tea during pregnancy was observed [OR: 4.4 (1.5–13)]. The results constitute additional evidence for a role of paternal smoking and suggest that maternal coffee and tea consumption during pregnancy may also increase the risk of CNS tumours. The study does not suggest an increased risk of CNS tumours related to alcohol consumption during pregnancy. © 2008 Lippincott Williams & Wilkins, Inc.