Research papers: Prostate CancerOccupational physical activity in relation with prostate cancer and benign prostatic hyperplasiaLagiou, Aretia b; Samoli, Evib; Georgila, Christinab; Minaki, Ploumib; Barbouni, Anastasiac; Tzonou, Anastasiab; Trichopoulos, Dimitriosd; Lagiou, Pagonab dAuthor Information aFaculty of Health Professions, Athens Technological Institute bDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens cDepartment of Public and Administrative Health, National School of Public Health, Athens, Greece dDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA Correspondence to Areti Lagiou, PhD, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, 75 M. Asias Street, Goudi, GR-115 27, Athens, Greece Tel: +30 210 746 2098; fax: +30 210 746 2080; e-mail: [email protected] Received 31 October 2007 Accepted 22 November 2007 European Journal of Cancer Prevention: August 2008 - Volume 17 - Issue 4 - p 336-339 doi: 10.1097/CEJ.0b013e3282f5221e Buy Metrics Abstract Using data from two case–control studies undertaken in Athens, Greece from 1994 to 1997, we have examined the association of occupational physical activity with the risk of prostate cancer and benign prostatic hyperplasia (BPH). Cases consisted of 320 patients with histologically confirmed incident prostate cancer and 184 patients with surgically treated BPH. Controls were 246 patients hospitalized for minor conditions. Occupations before retirement were classified, independently and blindly as to case–control status, into high, medium, and low physical activity levels. After fine controlling for years of schooling, there was a suggestive inverse association of physical activity with prostate cancer (P for trend 0.12) and a significant one with BPH (P for trend 0.04). The odds ratio (95% confidence interval) for high versus low activity was 0.69 (0.40–1.22) for prostate cancer and 0.59 (0.31–1.11) for BPH. The association of physical activity with both conditions tended to be more pronounced among men 65 years old or younger. Given the high frequency of occurrence of the examined conditions in the male population and our limited knowledge about other modifiable risk factors, preventive measures may have to focus on increasing physical activity. © 2008 Lippincott Williams & Wilkins, Inc.