The diagnosis of lobular carcinoma in situ (LCIS) provokes considerable anxiety in patients owing to misconceptions about this diagnosis. Initially LCIS was considered a premalignant lesion, but it is now a marker of increased risk. The number of women diagnosed with LCIS has increased in recent years most likely owing to more rigorous breast cancer screening. Implications of this diagnosis and management options are discussed in this review.
Departments of aMedicine
bSurgery, Wayne State University School of Medicine, Alexander J. Walt Comprehensive Breast Center, Karmanos Cancer Institute, Detroit, Michigan, USA
Correspondence to Nelia Afonso, MD, Department of Internal Medicine, 5C-WSU Health Center, 4201 St Antoine, Detroit, MI 48201-2153, USA
Tel: +31 3577 5030; fax: +31 3745 4707;
Received 20 March 2007 Accepted 29 August 2007