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Prostate cancer characteristics in the World Trade Center cohort, 2002–2013

Hashim, Danaa; Boffetta, Paolob,c; Galsky, Matthewb,c; Oh, Williamb,c; Lucchini, Robertoa,j; Crane, Michaela; Luft, Benjaming; Moline, Jaquelineh; Udasin, Irisi; Harrison, Denisef; Taioli, Emanuelad,e

European Journal of Cancer Prevention: July 2018 - Volume 27 - Issue 4 - p 347–354
doi: 10.1097/CEJ.0000000000000315
Research Papers: Prostate Cancer

An increased incidence of prostate cancer was reported in three cohorts of World Trade Center (WTC) respondents. It is uncertain whether this increase is because of WTC-related exposures or enhanced surveillance. Prostate cancer cases (2002–2013) were obtained from the WTC Health Program. Age, race, and Gleason score distribution were compared with New York State Cancer Registry cases from the same time period. Multivariate models were adjusted for age and race. Analyses of clinical characteristics of prostate cancer cases within the cohort were also carried out, adjusting for age, race, and WTC exposure categories. WTC respondents had a prostate cancer age-standardized rate ratio of 1.65 [95% confidence interval (CI): 1.37–1.93] compared with New York State; age-specific ratios were highest for ages 30–49 (2.28; 95% CI: 1.51–3.43), 70–74 (2.05; 95% CI: 1.03–4.10), and 80–84 years (5.65; 95% CI: 1.41–22.58). High WTC exposure was associated with advanced clinical stage (5.58; 95% CI: 1.05–29.76; Ptrend=0.03). WTC respondents continue to have a higher prostate cancer rate compared with New York State as a whole. Respondents with a higher WTC exposure level may have had more advanced clinical stage of prostate cancer.

aDepartment of Preventive Medicine

bTisch Cancer Institute

cDivision of Hematology and Medical Oncology

dInstitute for Translational Epidemiology

eDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai

fDepartment of Medicine, New York University School of Medicine, Bellevue Hospital Center, New York

gDepartment of Medicine, State University of New York at Stony Brook, Stony Brook

hDepartment of Occupational Medicine, Epidemiology and Prevention, Hofstra North Shore-LIJ School of Medicine, Great Neck, New York

iDepartment of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA

jDivision of Occupational Medicine, University of Brescia, Brescia, Italy

Correspondence to Dana Hashim, MD, MS, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, One Gustav L Levy Place New York, NY 10029, USA Tel: +1 212 824 7002; fax: +1 212 996 0407; e-mail:

Received June 16, 2016

Accepted September 9, 2016

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