Opinion: PDF OnlyConsumption of meat containing ractopamine might enhance tumor growth through induction of asparagine synthetaseFan, Frank S.Author Information Department of Medicine, Section of Haematology and Oncology, Ministry of Health and Welfare Taitung Hospital, Taitung County, Taiwan Received 22 November 2020 Accepted 30 November 2020 Correspondence to Frank S. Fan, MD, PhD, Department of Medicine, Ministry of Health and Welfare Taitung Hospital, No. 1, Wuquan Street, Taitung City, Taitung County 950, Taiwan, Tel: +886 89 324112, ext 1500; fax: +886 89 323891; e-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. European Journal of Cancer Prevention: January 7, 2021 - Volume - Issue - doi: 10.1097/CEJ.0000000000000655 Open PAP Metrics Abstract There is currently no evidence of the carcinogenic effect of the β-adrenergic agonist ractopamine added in finishing swine and cattle feed for promoting leanness. Nonetheless, it has the capability of stimulating expression of asparagine synthetase (ASNS) through activating transcription factor 5, and many other genes involved in the stress reaction in the skeletal muscle of pigs according to published scientific articles. Because overexpression of ASNS has been detected as a key player in amino acid response and unfolded protein response during the development of not a few malignant diseases, especially those with KRAS mutations, and found to be closely related to tumor proliferation, invasion and metastasis, it seems reasonable to hypothesize that intake of ractopamine residue in meat might bring negative effects to cancer patients. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.