Central nervous system cancerMGMT in glial carcinogenesis. Roles from prevention to treatmentElmaci, İlhana; Altinoz, Meric A.b; Kahraman Ozlu, Eylem Burcuc; Sari, Ramazana; Er, Ozlemd; Gokhan Ekmekci, Cumhure; Turkgenc, Burcuf; Ozpinar, Alpg; Hacker, Emilyg; Ozpinar, Ayselb Author Information aDepartment of Neurosurgery, Liv Hospital bDepartment of Biochemistry, Acibadem University cDepartment of Neurosurgery, Haydarpasa Numune Hospital dDepartment of Medical Oncology, Acibadem M.A.A. University, Istanbul, Turkey & Acibadem Maslak Hospital, Acibadem Healthcare Group, Istanbul, Turkey eDNA Laboratuari, Fulya fDepartment of Medical Biology, Faculty of Medicine, Istanbul Aydin University gUniversity of Pittsburgh, United States Received 2 November 2021 Accepted 10 February 2022 Correspondence to Ilhan Elmaci, MD, Department of Neurosurgery, Liv Hospital, Istanbul, Turkey, Tel: +90 536 563 23 66; e-mail: [email protected] European Journal of Cancer Prevention: November 2022 - Volume 31 - Issue 6 - p 568-576 doi: 10.1097/CEJ.0000000000000746 Buy Metrics Abstract Many investigations exist regarding the effect of the DNA repair enzyme MGMT (O6-methylguanine- DNA-methyltransferase)-encoding gene methylation on the antineoplasticity of temozolomide in glioblastoma patients. However, there exist surprisingly lesser studies regarding the associations between MGMT enzyme biochemistry with glial carcinogenesis. MGMT involves in risk of malignancies associated with ionizing radiation, smoking, exposure to polycyclic aromatic hydrocarbons, chlorinated solvents, vinylchloride and hairdyes. All these factors are also proposed to link with gliomagenesis, yet MGMT interactions with these carcinogens in gliomagenesis are not studied yet. In future, MGMT sequencing may be employed in vulnerable populations working in industries associated with exposure to these carcinogens to develop preventive strategies. Given that MGMT is involved in DNA repair, a polymorphism may simultaneously modify the risk of gliomas while enhancing temozolomide cytotoxicity in both marrow and tumor cells. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.