CarcinogenesisRole of microRNAs in the anticancer effects of the flavonoid luteolin: a systematic reviewMishan, Mohammad Amira; Khazeei Tabari, Mohammad Aminb,,c; Mahrooz, Abdolkarimd; Bagheri, Abouzard,,eAuthor Information aOcular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran bStudent Research Committee cUSERN Office dDepartment of Clinical Biochemistry and Medical Genetics, Molecular and Cell Biology Research Center eDepartment of Clinical Biochemistry and Medical Genetics, Gastrointestinal Cancer Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Received 2 April 2020 Accepted 30 October 2020 Correspondence to Abouzar Bagheri, PhD, Assistant Professor of Medical Genetics, Department of Clinical Biochemistry and Medical Genetics, Gastrointestinal Cancer Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, Tel: +98 9190278985; e-mail: [email protected], [email protected] European Journal of Cancer Prevention: September 2021 - Volume 30 - Issue 5 - p 413-421 doi: 10.1097/CEJ.0000000000000645 Buy Metrics Abstract Flavonoids, a broad class of polyphenolic compounds, can potentially have several therapeutic properties in human diseases, including protective effects against oxidative stress, inflammation, cardiovascular disease, diabetes, neurodegenerative disorders, and cancers. Luteolin as a member of flavonoids has been found to exhibit several anticancer properties mainly through cell apoptosis induction, inhibition of invasion, cell proliferation, network formation, and migration. Recent studies have revealed that phytochemicals such as luteolin may exert therapeutic properties through microRNAs (miRNAs or miRs), which have been emerged as important molecules in cancer biology in recent years. miRNAs, as a class of noncoding RNAs, have several important roles in cancer progression or regression. In this review, we aimed to summarize and discuss the role of miRNAs in the luteolin effects on different cancers. This review can be in line with the studies, which have shown that miRNAs may be potential therapeutic targets in cancer treatment. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.