Gastrointestinal CancerADCY2 rs10059539 C>T polymorphism confers a decreased risk of hepatocellular carcinoma in Chinese Han womenChao, Xua,,b; Miao, Fenga; Feng, Xuesongb; Shi, Hailongb; Wang, Yuewenb; Wu, Jieqionga; Zhao, Luyana; Zhang, Weia; Jiang, Chaoc,,aAuthor Information aThe Second Affiliated Hospital bThe College of Basic medicine, Shaanxi University of Chinese Medicine, Xianyang cThe Second Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi, China Received 25 March 2020 Accepted 1 September 2020 Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (www.eurjcancerprev.com). Correspondence to Chao Jiang, PhD, The Second Affiliated Hospital of Xi’an Medical University, Xi’an 710038, Shaanxi, China, Tel/Fax:+86 18092772526; e-mail: [email protected] European Journal of Cancer Prevention: September 2021 - Volume 30 - Issue 5 - p 351-356 doi: 10.1097/CEJ.0000000000000638 Buy SDC Metrics Abstract Objective Hepatocellular carcinoma (HCC) poses a serious threat to human health. ADCY2 gene polymorphisms may be related to HCC susceptibility. Therefore, we investigated whether ADCY2 gene polymorphisms are correlated to the risk of HCC in a Chinese Han population. Methods In a case-control study, we examined the associations between single nucleotide polymorphisms (SNPs) in ADCY2 and HCC risk. In 434 HCC cases and 442 healthy controls, we used the Agena MassARRAY platform to select and genotype four tag SNPs in ADCY2. We used logistic regression after adjusting for age and sex to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results The results showed that ADCY2 rs10059539 polymorphism was associated with a reduced susceptibility to HCC in women under the dominant model (TC/TT vs. CC; OR = 0.32; 95% CI = 0.13–0.83; P = 0.018) and the log-additive model (OR = 0.32; 95% CI = 0.13–0.83; P = 0.018). Conclusions Our results support the hypothesis that ADCY2 gene polymorphisms influence the genetic susceptibility to HCC. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.