Gastrointestinal cancerThe association between hypertension and colorectal cancer: a meta-analysis of observational studiesXuan, Kuna,,*; Zhao, Tianminga,,*; Sun, Chenyub; Patel, Akash S.c; Liu, Haixiaa; Chen, Xina; Qu, Guangboa; Sun, Yehuana,,dAuthor Information aDepartment of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China bAMITA Health Saint Joseph Hospital Chicago cUniversity of Illinois at Chicago College of Medicine, Chicago, Illinois, USA dCenter for Evidence-Based Practice, Anhui Medical University, Hefei, Anhui, China *Kun Xuan and Tianming Zhao contributed equally to the writing of this article. Received 30 October 2019 Accepted 30 December 2019 Corresponding au: Yehuan Sun, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China, Tel/fax: +86 551 65167725; e-mail: [email protected] European Journal of Cancer Prevention: January 2021 - Volume 30 - Issue 1 - p 84-96 doi: 10.1097/CEJ.0000000000000578 Buy Metrics Abstract The relationship between hypertension and risk of colorectal cancer (CRC) is unclear. This meta-analysis aims to explore the association between them. Six databases were searched for studies published before August 2019. The pooled relative risk (RR) and 95% confidence intervals (CIs) were calculated to estimate the association between the hypertension and CRC risk. A total of 2841 potentially relevant articles were obtained, and 25 studies with a pooled 1.95 million participants were finally included in the meta-analysis. These results suggested a positive association between hypertension and risk of CRC with a pooled RR of 1.15 (95% CI: 1.08, 1.23). Male patients with hypertension had a 13% (95% CI: 1.06, 1.20) increased risk of CRC. The risk of colon cancer and rectal cancer in male patients was 1.17 (95% CI: 1.01, 1.36) and 1.35 (95% CI: 1.04, 1.74), respectively, while no association between hypertension and the risk of CRC in females was elucidated. This meta-analysis demonstrated that a positive association between hypertension and CRC exists, with male patients having a higher risk of developing CRC than female patients. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.