Review Articles: Gynecological cancerTrends in prevalence in human papillomavirus types and their association with cervical dysplasia: an analysis on 15 138 women over 20 yearsBogani, Giorgio; Chiappa, Valentina; Pinelli, Ciro; Lopez, Salvatore; Signorelli, Mauro; Taverna, Francesca; Lombardo, Claudia; Ditto, Antonino; Raspagliesi, FrancescoAuthor Information Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy Received 9 October 2019 Accepted 2 December 2019 Correspondence to Giorgio Bogani, MD, PhD, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian 1, 20133 Milan, Italy, Tel: +00390223902392; fax: +00390223902349; e-mail: firstname.lastname@example.org European Journal of Cancer Prevention: September 2020 - Volume 29 - Issue 5 - p 452-457 doi: 10.1097/CEJ.0000000000000565 Buy Metrics Abstract To investigate trends in prevalence of various human papillomavirus types in order to assess the unmet clinical needs for women affected by human papillomavirus-related disease. Data of consecutive 15 138 patients undergoing human papillomavirus DNA testing from 1998 to 2018 were retrospectively identified. Human papillomavirus types were classified at high-risk according to the classification of the International Agency for Research on Cancer. The International Agency for Research on Cancer included seven human papillomavirus types covered by nine-valent vaccine and five not yet covered by any available vaccines. Overall, 4159 (65.3%), 1500 (23.5%) and 714 (11.2%) women had human papillomavirus types covered by nine-valent vaccination, not covered by nine-valent vaccination and co-infections of human papillomavirus types of both groups. At least one high-risk human papillomavirus type(s) was detected in 1241 patients with genital dysplasia: 832 (67.1%), 291 (23.4%) and 118 (9.5%) women had human papillomavirus types covered by nine-valent vaccination, not covered by nine-valent vaccination and co-infections of human papillomavirus types of both groups. Over the twenty-year study period, the number of human papillomavirus types not covered by nine-valent vaccine increased dramatically (from 4 to 16%; P < 0.001, P for trend). Similarly, looking at patients with genital dysplasia, high-risk human papillomavirus types not covered by nine-valent vaccine increased from 3 to 13% (P < 0.001, P for trend). Our data highlight that human papillomavirus types covered by nine-valent vaccine represent are the main types associated with genital dysplasia. However, over the study period, we observed an increasing prevalence of confections and high-risk human papillomavirus types not covered by the nine-valent vaccine, thus suggesting the need of developing more complete vaccines against human papillomavirus. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.