Research Articles: HeadlineProgress in cancer mortality, incidence, and survival: a global overviewSantucci, Claudiaa; Carioli, Gretaa; Bertuccio, Paolab; Malvezzi, Matteoa; Pastorino, Ugoc; Boffetta, Paolod,,e; Negri, Evab; Bosetti, Cristinaf; La Vecchia, CarloaAuthor Information aDepartment of Clinical Sciences and Community Health bDepartment of Biomedical and Clinical Sciences ‘L. Sacco’, Università degli Studi di Milano cThoracic Surgery Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy dTisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, New York eDepartment of Medical and Surgical Sciences, University of Bologna, Bologna fDepartment of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy Received 24 March 2020 Accepted 27 March 2020 Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (www.eurjcancerprev.com). Correspondence to: Prof. Carlo La Vecchia, MD, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, via Augusto Vanzetti 5 – 20122 Milan, Italy, Tel: +39 0250320863; fax: +39 0250320866; e-mail: firstname.lastname@example.org European Journal of Cancer Prevention: September 2020 - Volume 29 - Issue 5 - p 367-381 doi: 10.1097/CEJ.0000000000000594 Buy SDC Metrics Abstract Cancer mortality has declined over the last three decades in most high-income countries reflecting improvements in cancer prevention, diagnosis, and management. However, there are persisting and substantial differences in mortality, incidence, and survival worldwide. In order to provide an up-to-date overview of trends in mortality, incidence, and survival, we retrieved data from high-quality, population-based cancer registries for all cancers and 10 selected cancer sites in six high-income countries and the European Union. We computed age-standardized (world standard population) mortality and incidence rates, and applied joinpoint regression models. Mortality from all cancers and most common cancer sites has declined over the last 25 years, except for the pancreas and lung (in women). The patterns for incidence are less consistent between countries, except for a steady decrease in stomach cancer in both sexes and lung cancer in men. Survival for all cancers and the selected cancer sites increased in all countries, even if there is still a substantial variability. Although overall cancer death rates continue to decline, incidence rates have been levelling off among men and have been moderately increasing among women. These trends reflect changes in cancer risk factors, screening test use, diagnostic practices, and treatment advances. Many cancers can be prevented or treated effectively if they are diagnosed early. Population-based cancer incidence and mortality data can be used to focus efforts to decrease the cancer burden and regularly monitor progress towards cancer control goals. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.