Review Articles: Lung cancerPrognostic effect of implementation of the mass low-dose computed tomography lung cancer screening program: a hospital-based cohort studyWu, Fu-Zonga,,b,,c; Huang, Yi-Luana,,b,,c; Wu, Yun-Jua; Tang, En-Kueid,,e; Wu, Ming-Tinga,,b,,c; Chen, Chi-Shenf; Lin, Yun-Peia,,b,,cAuthor Information aDepartment of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan bFaculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan cInstitute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan dDepartment of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan eDepartment of Nursing, Shu-Zen Junior College of Medicine and Management fPhysical Examination Center, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan Received 7 August 2019 Accepted 5 November 2019 Correspondence to Yun-Pei Lin, MD, Section of Thoracic and Circulation Imaging, Department of Radiology, Kaohsiung Veterans General Hospital, Taiwan No.386, Ta-Chung 1st Road, Kaohsiung 81362, Taiwan, Tel: +886 7 342 2121; fax: +886 7 346 8301; e-mail: email@example.com European Journal of Cancer Prevention: September 2020 - Volume 29 - Issue 5 - p 445-451 doi: 10.1097/CEJ.0000000000000569 Buy Metrics Abstract Low-dose computed tomography lung cancer screening aims to detect early-stage lung cancers in order to decrease the incidence of advanced-stage lung cancers and to reduce lung cancer mortality. We analyzed the time trends of lung cancer stage distribution and mortality rates after the gradual implementation of the low-dose computed tomography lung cancer screening in a hospital-based cohort. Using the hospital-based cancer registry data on lung cancer number and death from 2007 to 2014, we aim to evaluate the trends in stage distribution and mortality rate after the gradual implementation of low-dose computed tomography lung cancer screening program over recent years. From 2007 to 2014, overall 2542 cases of lung cancers were diagnosed according to hospital-based cancer registry. For the 1-year mortality rate, the mortality rate decreased gradually from 48.16 to 37.04% between 2007 and 2014. For the 5-year mortality rate, the mortality rate decreased gradually from 88.49 to 69.44% between 2007 and 2014. There was a gradual decrease in stage IV lung cancer with the corresponding sharp increase in stage I early lung cancer after following the implementation of the large volume of the low-dose computed tomography examination between the years 2011 and 2014. In conclusion, these results suggest that the gradual implementation of low-dose computed tomography lung screening program could lead to a remarkable decrease in lung cancer mortality and a remarkable stage shift in the trend over time in this hospital-based cohort. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.