Research Papers: Gastrointestinal CancerThe correlation between IL-4 polymorphisms and colorectal cancer risk in a population in Northwest ChinaWen, Xiulina,,b; Xin, Xiaa; Li, Jieqionga; Qiao, Linaa; Liu, Fangc; Guo, Yuana; Qu, Zhanb; Wang, Ruia; Li, XiaomeibAuthor Information aThe First Affiliated Hospital of Xi’an Jiaotong University bSchool of Nursing, Health Science Center, Xian Jiaotong University, Shaanxi cSchool of Nursing, Shaanxi University of Chinese Medicine, Xi'an, China Received 5 November 2018 Accepted 19 December 2018 Supplemental digital content is available for this article. Direct URL citationsappear in the printed text and are provided in the HTML and PDF versions of thisarticle on the journal's website, www.eurjcancerprev.com. Correspondence to Xiaomei Li, PhD, School of Nursing, Health Science Center, Xi’an Jiaotong University, #76, Yanta West Road, Xi’an, Shaanxi 710061, China Tel: + 86 137 0022 1963; e-mail: email@example.com European Journal of Cancer Prevention: March 2020 - Volume 29 - Issue 2 - p 95-99 doi: 10.1097/CEJ.0000000000000503 Buy SDC Metrics Abstract Our aim was to investigate whether polymorphisms in the interleukin-4 (IL-4) gene are associated with the risk of colorectal cancer (CRC) in a Chinese Han population. Six single-nucleotide polymorphisms (SNPs) in the IL-4 were genotyped by Agena MassARRAY in 248 CRC patients and 463 healthy controls. The association of IL-4 polymorphisms with CRC risk was assessed by genetic models, linkage disequilibrium, and haplotype analyses. The results suggested that the CC genotype of rs2243250 confers a lower risk of CRC in the recessive model [odds ratio (OR) = 0.42, 95% confidence interval (CI): 0.19–0.92, P = 0.020]. Similarly, rs2227284 GG was associated with a reduced risk of CRC in the codominant (OR = 0.18, 95% CI: 0.04–0.82, P = 0.027) and recessive (OR = 0.19, 95% CI: 0.04–0.83, P = 0.008) models adjusted for age. Our findings suggested that rs2243250 and rs2227284 in IL-4 are associated significantly with reduced CRC risk, which may facilitate the identification of CRC patients in Chinese populations. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.