Breast CancerThe impact of depression on adherence to organized and opportunistic breast cancer screeningMontagna, Giacomoa,,b,,*; Schneeberger, Andres R.d,,g,,j,,*; Rossi, Lorenzoh,,i; Reina, Hubertinab; Schwab, Fabienne D.a,,b; Schoetzau, Andreasb; Eichholzer, Monikae; Pagani, Oliviah,,i; Weber, Walter P.a; Kurzeder, Christiana,,b; Güth, Uwef; Huber, Christian G.cAuthor Information aBreast Center bDepartment of Obstetrics and Gynecology, University Hospital of Basel cPsychiatric University Hospital (UPK), University of Basel, Basel dDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry (PUK) eDivision of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich fBreast Center Zurich, Zurich gPsychiatric Services Grisons (PDGR), Chur hBreast Unit of Southern Switzerland (CSSI), Lugano iOncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland jDepartment of Psychiatry and Behavioral Sciences (AECOM), Albert Einstein College of Medicine, New York, New York, USA Received 17 January 2019 Accepted 25 March 2019 * Giacomo Montagna and Andres R. Schneeberger contributed equally to the writing of this article. This study was presented in part as a poster at the 16th St. Gallen International Breast Cancer Conference, 20-23 March 2019, Vienna, Austria. Correspondence to Giacomo Montagna, MD, Department of Obstetrics and Gynecology and Breast Center, University Hospital Basel, 4056 Basel, Switzerland, Tel: + 41 613 287 991; fax: + 41 612 659 185; e-mail: firstname.lastname@example.org European Journal of Cancer Prevention: January 2020 - Volume 29 - Issue 1 - p 53–59 doi: 10.1097/CEJ.0000000000000520 Buy Metrics Abstract One in five women will experience depression over her lifetime, and one out of eight will develop breast cancer. We evaluated the effect of depression on adherence to mammography in Switzerland, where opportunistic and organized screening programs coexist. We analyzed data from 3206 women aged 50–69 who participated in the Swiss Health Survey 2012. We compared mammographic rates among women with no to mild versus moderate to severe depressive symptoms. The effect of the type of screening on the odds of undertaking a mammography was calculated using multivariable logistic regression analysis. Women with moderate to severe major depressive symptoms were more likely to have had a mammography in the previous 2 years than their nondepressed or less-depressed counterparts (51 vs. 39.2%, respectively, P = 0.005). In the multivariable analysis, women with no to mild major depression living in cantons with an organized screening program had an adjusted odds ratio of 2.7 (95% confidence interval: 2.30–3.17, P < 0.001) of having had a mammography within the past 24 months compared with those living in the regions with an opportunistic screening. The adjusted odds ratio for women with moderate to severe major depression was 4.21 (95% confidence interval: 2.13–8.33, P < 0.001). In Switzerland. adherence to mammographic screening among women with moderate to severe major depression is higher than among women with no or minimal major depressive symptoms. This increased adherence is even more pronounced in regions with organized screening. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.