Gastrointestinal CancerDoneness preferences, meat and meat-derived heterocyclic amines intake, and N-acetyltransferase 2 polymorphisms: association with colorectal adenoma in Japanese BraziliansBudhathoki, Sanjeeva; Iwasaki, Motokia; Yamaji, Taikia; Hamada, Gerson S.b; Miyajima, Nelson T.c,,d; Zampieri, Jose C.d; Sharma, Sangitae; Pakseresht, Mohammadrezae,,f; Kolahdooz, Faribae; Ishihara, Junkoa; Takachi, Ribekaa; Charvat, Hadriena; Marchand, Loïic Leg; Tsugane, ShoichiroaAuthor Information aEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan bNikkei Disease Prevention Center cSBC Hospital dNipo-Brasileiro Hospital, São Paulo, Brazil eIndigenous and Global Health Research Group, Department of Medicine fDepartment of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada gEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA Received 2 July 2018 Accepted 29 October 2018 Supplemental digital content is available for this article. Direct URL citationsappear in the printed text and are provided in the HTML and PDF versions of thisarticle on the journal's website, www.eurjcancerprev.com. Correspondence to Motoki Iwasaki, PhD, Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan Tel: + 81 335 422 511; fax: + 81 335 478 578; e-mail: [email protected] European Journal of Cancer Prevention: January 2020 - Volume 29 - Issue 1 - p 7-14 doi: 10.1097/CEJ.0000000000000506 Buy SDC Metrics Abstract Intake of heterocyclic amines (HCAs) and other mutagenic compounds formed during cooking has been hypothesized to be responsible for the positive association observed between red meat and colorectal cancer. We evaluated whether well-done/very well-done preferences for various meat and fish items, higher intakes of meat and fish, and meat-derived and fish-derived HCA are associated with the risk of colorectal adenoma (CRA) in a Japanese–Brazilian population. We selected 302 patients with adenoma and 403 control individuals who underwent total colonoscopy between 2007 and 2013, and collected information on aspects of meat intake using a detailed questionnaire. We also estimated HCA intake of the study participants using an HCA database that matched the cooking methods of this population. Latent class analysis on the basis of response to doneness preferences for different cooking methods of commonly consumed meat and fish items identified four distinct subgroups. Compared with the subgroup characterized by a preference for rare/medium well-done cooking for most meat and fish items, the odds ratio of CRA for the well-done/very well-done preference subgroup was 1.19 (95% confidence interval: 0.51–2.75). High intake of mixed-meat dishes was suggestively associated inversely with CRA, whereas a high intake of poultry was associated positively with CRA. No clear association with intake of total or specific HCAs and no effect modification by N-acetyltransferase 2 acetylation genotype were observed. We found no statistically significant associations between meat and HCA intake and CRA. These findings do not support a positive association between meat and meat-derived HCA intake and the risk of CRA. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.