Research Papers: Gastrointestinal CancerCruciferous vegetable intake and colorectal cancer risk: Japan public health center-based prospective studyMori, Nagisaa; Sawada, Noriea; Shimazu, Taichia; Yamaji, Taikia; Goto, Atsushia; Takachi, Ribekab; Ishihara, Junkoc; Iwasaki, Motokia; Inoue, Manamia; Tsugane, Shoichiroa; the JPHC Study GroupAuthor Information aEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan bDepartment of Food Science and Nutrition, Faculty of Human Life and Environment, Nara Women’s University, Nara, Japan cSchool of Life and Environmental Science, Department of Food and Life Science, Azabu University, Kanagawa, Japan Received 29 May 2018 Accepted 30 August 2018 Supplemental digital content is available for this article. Direct URL citationsappear in the printed text and are provided in the HTML and PDF versions of thisarticle on the journal's website, www.eurjcancerprev.com. Correspondence to Norie Sawada, MD, PhD, Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan Tel: + 81 335 475 201 x3336; fax: + 81 335 478 578; e-mail: [email protected] European Journal of Cancer Prevention: September 2019 - Volume 28 - Issue 5 - p 420-427 doi: 10.1097/CEJ.0000000000000491 Buy SDC Metrics Abstract We aimed to assess the association between cruciferous vegetable intake and colorectal cancer (CRC) development among Japanese adults aged between 45 and 74 years in the Japan Public Health Center-based Prospective Study. During 1 325 853 person-years of follow-up, 2612 CRC cases were identified. The association of cruciferous vegetable intake with CRC risk was assessed using a Cox proportional hazard regression model to compute hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. No significant association was observed between the highest cruciferous vegetable intake quartile (compared with the lowest) and CRC risk in men (multivariate HRs: 1.08; 95% CI: 0.91, 1.29) and women (multivariate HRs: 0.99; 95% CI: 0.80, 1.22) and its subsites. Women showed a marginal negative association between cruciferous vegetable intake and the risk of colon cancer (CC) after excluding participants who developed CC in the first 3 years of follow-up (P for trend = 0.08); a positive association was found with proximal CC in men. Cruciferous vegetable intake does not have a significant association with CRC risk in the Japanese general population. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.