Research Papers: Gastrointestinal CancerRed meat intake, CYP2E1 and PPARγ polymorphisms, and colorectal cancer riskKim, Na-Huia; Seol, Ju Euna; Kim, Jeongseong; Lee, Bong-Hwah; Hwang, Dae-Yongb; Jeong, Jinyounge; Lee, Hun-Jaef; Ahn, Yoon-Okc; Kim, Dong-Hyune; Lee, Jung Eund Author Information aDepartment of Food and Nutrition, Sookmyung Women’s University bDepartment of Surgery, Konkuk University Medical Center cDepartment of Preventive Medicine, Seoul National University dDepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul eDepartment of Social and Preventive Medicine, Hallym University, Chuncheon fDepartment of Social and Preventive Medicine, Inha University College of Medicine, Incheon gDepartment of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang hDepartment of Surgery, Hallym University College of Medicine, Anyang, Korea Correspondence to Jung Eun Lee, ScD, Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea Tel: +82 2880 6834; fax: +82 2884 0305; e-mail: [email protected] European Journal of Cancer Prevention: July 2019 - Volume 28 - Issue 4 - p 304-310 doi: 10.1097/CEJ.0000000000000462 Buy Metrics Abstract The association between red meat intake and colorectal cancer (CRC) may be modulated by genetic polymorphisms of cytochrome P450 2E1 (CYP2E1), a key enzyme in the metabolism of nitrosamines, and peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor involved in adipogenesis and lipid and glucose metabolism. We conducted a case–control study of 971 patients with CRC and 658 controls who were admitted to two university hospitals between 1995 and 2004 in Seoul, Korea. Participants were asked about red meat intake by using a validated food frequency questionnaire. Polymorphisms of CYP2E1 (rs3813867) and PPARγ (rs1801282 or rs3856806) were identified using the TaqMan assay. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression models. We found that the association between red meat and CRC varied by CYP2E1 polymorphisms; ORs (95% CIs) for at least five or more vs. less than one time/week of red meat intake were 2.77 (1.23–6.25) among individuals with C alleles of CYP2E1 and 0.89 (0.51–1.54) among individuals with the GG allele (Pinteraction=0.05). Compared with those individuals with the CC allele, increasing risk of CRC with increasing red meat intake was more pronounced among individuals with T alleles of PPARγC161T (rs3856806), but the association was not significant. Our data provide evidence that East Asians with the variant type of CYP2E1 may have high susceptibility to development of CRC risk. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.