Research Papers: Gastrointestinal CancerHelicobacter pylori seroprevalence in Spain: influence of adult and childhood sociodemographic factorsLorenzo, Irenea,b; Fernández-de-Larrea, Nereac,d; Michel, Angelika*; Romero, Beatrize,g; Lope, Virginiac,d; Bessa, Xavierh; Moreno, Victord,i,m; Martín, Vicented,o; Amiano, Pilard,p; Castilla, Jesúsd,r; Tardón, Adoninad,s; Dierssen-Sotos, Trinidadd,t; Peiró, Rosanad,u; Díaz-Santos, Marianv; Navarro, Carmend,w,x; Jiménez-Moleón, José J.d,y,z; Butt, Juliae; Barricarte, Aureliod,r; Ruiz, Iruneq; Molina-de-la-Torre, Antonio J.d,o; Casabonne, Delphined,n; Pérez-Gómez, Beatrizc,d; Kogevinas, Manolisd,j,k,l; del Campo, Rosae,g; de Sanjosé, Silviad,n; Pollán, Marinac,d; Waterboer, Tim*; Aragonés, Nuriad,f Author Information aUniversity Hospital of Guadalajara (SESCAM), Guadalajara bTeaching Unit of Preventive and Public Health, Institute of Health Sciences, Talavera de la Reina cCancer and Environmental Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III dConsortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP) eDepartment of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Health Research Institute fDepartment of Health, Epidemiology Section, Public Health Division, Madrid gSpanish Network for Research in Infectious Diseases hGastroenterology Department, Hospital del Mar iDepartment of Clinical Sciences, Faculty of Medicine, University of Barcelona jISGlobal, Centre for Research in Environmental Epidemiology (CREAL) kIMIM (Hospital del Mar Medical Research Institute) lPompeu Fabra University, Barcelona mCancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL nCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat oResearch Group in Gene-Environment Interactions and Health, University of León, Leon pPublic Health Division of Gipuzkoa, BioDonostia Research Institute qDepartment of Pathology, Donostia University Hospital, Donostia rNavarra Institute for Health Research (IdiSNA), Pamplona sOncology Institute, University of Oviedo, Oviedo tUniversity of Cantabria –Marqués de Valdecilla Research Institute (IDIVAL), Santander uFoundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), Valencia vNatural Resources, Health and Environment Research Center, University of Huelva, Huelva (RENSMA) wDepartment of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca xDepartment of Health and Social Sciences, University of Murcia, Murcia yGranada Health Research Institute (ibs.GRANADA) zDepartment of Preventive Medicine and Public Health, University of Granada, Granada, Spain *Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer (DKFZ), Research Center, Heidelberg, Germany Correspondence to Nuria Aragonés, PhD, MD, PHM, Subdirección General de Epidemiología, Dirección General de Salud Pública, Consejería de Sanidad de la Comunidad de Madrid, C/San Martín de Porres 6, 28035 Madrid, Spain Tel: +34 913 700 121; fax: +34 913 700 883; e-mail: [email protected] European Journal of Cancer Prevention: July 2019 - Volume 28 - Issue 4 - p 294-303 doi: 10.1097/CEJ.0000000000000483 Buy SDC Metrics Abstract Helicobacter pylori (H. pylori) chronic infection causes severe digestive diseases, including gastric cancer, and certain strains entail a higher risk. Risk factors for this infection are still not fully understood. The aim of this study was to describe the association of adult and childhood sociodemographic factors with the seroprevalence of H. pylori, and with CagA and VacA antigen-specific seropositivity among H. pylori-seropositive individuals in the Spanish adult population. Serum antibody reactivity to H. pylori proteins was evaluated using multiplex serology in 2555 population-based controls enrolled in the MCC-Spain study, a multicase–control study recruiting participants from 2008 to 2013 in different areas of Spain. H. pylori seroprevalence was defined as seropositivity against at least four bacterial proteins. Information on sociodemographics, lifestyles, and environmental exposures was collected through personal interviews. Prevalence ratios and 95% confidence intervals were estimated using Poisson regression models to assess the association of lifetime sociodemographic factors with H. pylori seroprevalence and with seropositivity for CagA and VacA. H. pylori seroprevalence was 87.2%. Seropositivity was statistically significantly higher in men, increased with age, BMI, and number of siblings, and decreased with education and socioeconomic family level at birth. Among H. pylori-seropositive individuals, seropositivity was 53.3% for CagA, 61.4% for VacA, and 38.8% for both CagA and VacA. Ever smokers had lower seroprevalence for CagA and VacA than never smokers. H. pylori seroprevalence among this Spanish adult population was high and one third of the population was seropositive for two well-known markers of gastric cancer risk: CagA and VacA. Sex, age, education, and BMI were associated with H. pylori seroprevalence. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.