Research Papers: Gastrointestinal CancerDietary and serum vitamins A and E and colorectal cancer risk in Chinese population: a case–control studyLuo, Honga,b,*; Fang, Yu-Jingc,d,*; Lu, Min-Shana,e; Pan, Zhi-Zhongc; Huang, Jinga; Chen, Yu-Minga; Zhang, Cai-Xiaa,bAuthor Information aDepartment of Medical Statistics and Epidemiology bGuangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University cDepartment of Colorectal Surgery dDepartment of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine eGuangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, People’s Republic of China *Hong Luo and Yu-Jing Fang contributed equally to the writing of this article. Correspondence to Cai-Xia Zhang, PhD, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, People’s Republic of China Tel: +86 208 733 1943; fax: +86 208 733 0446; e-mail: [email protected] European Journal of Cancer Prevention: July 2019 - Volume 28 - Issue 4 - p 268-277 doi: 10.1097/CEJ.0000000000000452 Buy Metrics Abstract The effect of vitamin A (VA) and vitamin E (VE) on colorectal cancer (CRC) risk is controversial. The aim of this study is to examine the association between serum concentrations and dietary intakes of VA and VE and the risk of CRC in Guangdong, China. A total of 535 cases and 552 sex and age-matched (5-year interval) controls were recruited during July 2010 to September 2014. Dietary information was assessed by face-to-face interviews using a validated food frequency questionnaire. Concentrations of VA and VE were measured by high-performance liquid chromatography. Multivariable logistic regression was used to estimate the odds ratios (ORs) and 95% confidence interval (CI) after adjusting for various potential confounders. A higher intake of VA and VE was found to be associated with 52 and 43% reduction in CRC risk. The ORs of the highest quartile compared with the lowest quartile intake were 0.48 (95% CI: 0.31, 0.73, Ptrend<0.01) for VA and 0.57 (95% CI: 0.37, 0.88, Ptrend<0.01) for VE. An inverse association was also found between serum retinol and CRC risk, with an adjusted OR (95% CI) of 0.28 (0.19–0.43) (Ptrend<0.01). However, no statistically significant association was found between serum α-tocopherol and CRC risk. Stratified analysis by sex showed that serum retinol and dietary VA and VE were inversely associated with CRC risk in both sexes. This study supported the hypothesis that lower serum levels of retinol and lower intakes of VA and VE were associated with the risk of CRC in a Chinese population. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.