Research Papers: Gastrointestinal CancerWine consumption and colorectal cancer risk: a meta-analysis of observational studiesXu, Weisonga; Fan, Huia; Han, Zhijuana; Liu, Yufenga; Wang, Yipinga; Ge, ZhenmingbAuthor Information aDepartment of Gastroenterology, the Second People’s Hospital of Nantong bDepartment of Gastroenterology, the First People’s Hospital of Nantong, Nantong, Jiangsu, China Correspondence to Zhenming Ge, MD, Department of Gastroenterology, the First People’s Hospital of Nantong, 6 Haierxiang North Road, Nantong, Jiangsu 226001, China Tel/fax: +86 513 8506 1003; e-mail: [email protected] European Journal of Cancer Prevention: May 2019 - Volume 28 - Issue 3 - p 151-158 doi: 10.1097/CEJ.0000000000000444 Buy SDC Metrics Abstract There were inconsistent results with respect to the correlation between consumption of wine and the development of colorectal cancer (CRC). We carried out a meta-analysis to investigate this issue. We included observational studies on the aforementioned relationship according to a literature search of Embase and Pubmed from inception till 28 February 2017. The summary relative risk (SRR) and 95% confidence intervals (CI) were calculated using a random-effects model. A total of eight case–control and nine cohort studies were identified, involving 12 110 CRC cases. The study showed that wine drinking was not associated with any greater risk for CRC (SRR=0.99, 95% CI: 0.89–1.10; Pheterogeneity<0.001) compared with nondrinkers. The subgroup analyses indicated that null associations were observed in men and women for colon and rectal cancer. Neither light to moderate (<2 drinks/day; SRR=0.93, 95% CI: 0.80–1.08, I2=69.2%) nor heavy (≥2 drinks/day; SRR=1.00, 95% CI: 0.86–1.16, I2=39.9%) consumption of wine was associated statistically with CRC risk. This meta-analysis suggests that any wine consumption was not associated with the risk of CRC. Null associations were shown in men and women for colon and rectal cancer. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.