Research Papers: Gastrointestinal CancerA case–control study of risk factors for colorectal cancer in an African populationKatsidzira, Leolina,e; Gangaidzo, Innocent Ta; Makunike-Mutasa, Rudob; Manyanga, Tadiosa; Matsena-Zingoni, Zvifadzod; Thomson, Sandiee; Matenga, Jonathan Aa; Rusakaniko, Simbarashec; Ramesar, RajfAuthor Information Departments of aMedicine bHistopathology cCommunity Medicine, College of Health Sciences, University of Zimbabwe dNational Institute of Health Research, Harare, Zimbabwe eDepartment of Medicine, Division of Gastroenterology, University of Cape Town and Groote Schuur Hospital fMRC/UCT Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa Correspondence to Leolin Katsidzira, MMed(Med), Department of Medicine, College of Health Sciences, University of Zimbabwe, PO Box A178, Avondale, Harare, Zimbabwe Tel: +263 4 731000; fax: +263 4 251017; e-mail: [email protected] European Journal of Cancer Prevention: May 2019 - Volume 28 - Issue 3 - p 145-150 doi: 10.1097/CEJ.0000000000000439 Buy Metrics Abstract The interplay between hereditary and environmental factors in the causation of colorectal cancer in sub-Saharan Africa is poorly understood. We carried out a community based case–control study to identify the risk factors associated with colorectal cancer in Zimbabwe. We recruited 101 cases of colorectal cancer and 202 controls, matched for age, sex and domicile. Potential risk factors including family history, socioeconomic status, urbanization, diabetes mellitus and previous schistosomiasis were evaluated. Conditional logistic regression was used to estimate the odds ratios associated with the different factors. Cases were more likely to have a tertiary education (32.7 vs. 13.4%, P<0.001) and a higher income (18.8 vs. 6.9%, P=0.002). After multivariate analysis, diabetes mellitus [odds ratio (OR): 5.3; 95% confidence interval (CI): 1.4–19.9; P=0.012], previous urban domicile (OR: 2.8; 95% CI: 1.0–7.8; P=0.042), previous schistosomiasis (OR: 2.4; 95% CI: 1.4–4.2; P=0.001) and cancer in a first-degree relative (OR: 2.4; 95% CI: 1.2–4.8; P=0.018) were associated independently with colorectal cancer. Our findings suggest that family history, diabetes mellitus, previous schistosomiasis and approximation to a western lifestyle are the predominant associations with colorectal cancer in Africans. This offers opportunities for targeted prevention and hypothesis-driven research into the aetiology of colorectal cancer in this population. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.