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Role of polyphenols and nonpolyphenols against toxicity induced by fluoride

a comprehensive review

Claudio, Samuel R.a; Handan, Bianca A.b; Gomes de Moura, Carolina F.b; Viana, Milena de Barrosb; Yamauchi, Liria Y.c; Aguiar, Odair Jrb; Oshima, Celina T.F.a; Ribeiro, Daniel A.a

European Journal of Cancer Prevention: March 2019 - Volume 28 - Issue 2 - p 109–114
doi: 10.1097/CEJ.0000000000000424
Review Article: Lifestyle

Since its discovery as an antimicrobial agent, fluoride has been used in the control of dental caries. Many studies have shown that the chronic exposure of fluoride in high concentrations causes adverse effects in multiple organs; the use of bioactive compounds present in foods as a tool to mitigate the effects of fluoride could potentially be useful for populations in different parts of the world are exposed to fluoride in a chronic and systemic way. Thus, the aim of this comprehensive review is to present and discuss the published papers that focused on the use of polyphenols and nonpolyphenols that can mitigate the harmful activities promoted by fluoride exposure. Certainly, these data will contribute toward a better understanding of the role of food compounds in the pathological outcomes induced by fluoride. The new information will be added to that already available for regulatory purposes as a safe way to promote oral healthcare and prevent oral carcinogenesis.

Departments of aPathology


cHuman Movement Sciences, Federal University of São Paulo, UNIFESP, Santos, Brazil

Correspondence to Daniel A. Ribeiro, DDS, PhD, Department of Biosciences, Federal University of São Paulo, UNIFESP, Av. Ana Costa, 95, Vila Mathias, Santos 11060-001, Brazil Tel: +55 133 878 3774; fax: +55 132 290 100; e-mail:

Received February 23, 2017

Accepted July 13, 2017

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