Research Papers: Gastrointestinal CancerAssociation between alcohol consumption and colorectal cancer risk: a case–control study in the Han Chinese populationWang, Yuea; Yang, Helend; Shen, Chun-Jianb; Ge, Jin-Nianc; Lin, JieaAuthor Information aDepartment of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute bDepartment of Surgery, the Second Hospital of Shenyang Medical College cDepartment of Surgery, the First Hospital of China Medical University, Shenyang, China dInstitute of Public Health, University of California, San Francisco, California, USA Correspondence to Jie Lin, MD, Department of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China, 44 Xiaoheyan Road, Dadong District, Shenyang 110042, China Tel: +86 135 142 12975; fax: +86 024 319 16220; e-mail: [email protected] European Journal of Cancer Prevention: September 2018 - Volume 27 - Issue 5 - p 433-437 doi: 10.1097/CEJ.0000000000000355 Buy Metrics Abstract Many epidemiologic studies have reported that alcohol is a risk factor for colorectal cancer. To further evaluate the association, we carried out a case–control study in the Han Chinese population. From February 2008 to February 2013, we carried out a hospital-based case–control study on colorectal cancer. Information was collected using a questionnaire. Cases were 310 patients with colorectal cancer; 620 healthy matched controls were also recruited. Multiple logistic regression was used to estimate the odds ratios (OR) and the corresponding 95% confidence intervals. Alcohol consumption was associated with increased colorectal cancer risk, but OR was significant only among heavy drinkers (OR=2.18, for ≥21 drinks/week). Colorectal cancer risk was 4.01-fold higher in heavy smokers (≥20 cigarettes/day) and heavy drinkers (≥21 drinks/week) in comparison with never smokers who consumed less than 7 drinks/week. The relationship was strengthened by stratified studies of sex. Among former drinkers, the excess of risk disappeared in those who had quit for at least 10 years (OR=0.86). Our study confirmed that heavy alcohol consumption was associated with an increasing risk of colorectal cancer; smoking modified this relationship, especially heavy smokers. Further data from large cohorts are desirable for conclusive confirmation. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.