Review Article: Gynecological CancerGenital use of talc and risk of ovarian cancer: a meta-analysisBerge, Weraa; Mundt, Kennethb; Luu, Hungc; Boffetta, PaolodAuthor Information aFaculty of Medicine, University of Dresden, Dresden, Germany bRamboll Environ, Amherst, Massachusetts cUniversity of South Florida College of Public Health, Tampa, Florida dIcahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, New York, USA Correspondence to Paolo Boffetta, MD, MPH, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, One Gustave L. Levy Place, Box 1130, New York, NY 10029, USA Tel: +1 212 824 7378; fax: +1 212 849 2566; e-mail: [email protected] European Journal of Cancer Prevention: May 2018 - Volume 27 - Issue 3 - p 248-257 doi: 10.1097/CEJ.0000000000000340 Buy SDC Metrics Abstract Some epidemiological studies suggest an association between genital use of talc powders and increased risk of ovarian cancer, but the evidence is not consistent. We performed a meta-analysis of epidemiological studies to formally evaluate this suspected association. A systematic search was conducted in Medline, Embase, and Scopus, leading to the identification of 24 case–control studies and three cohort studies. In the meta-analysis, we used a random-effect model to calculate summary estimates of the association between genital use of talc and occurrence of ovarian cancer. We assessed potential sources of between-study heterogeneity and presence of publication bias. The summary relative risk (RR) for ever use of genital talc and ovarian cancer was 1.22 [95% confidence interval (CI): 1.13–1.30]. The RR for case–control studies was 1.26 (95% CI: 1.17–1.35) and for cohort studies was 1.02 (95% CI: 0.85–1.20, Pheterogeneity=0.007). Serous carcinoma was the only histologic type for which an association was detected (RR: 1.24; 95% CI: 1.15–1.34). There was a weak trend in RR with duration and frequency of genital talc use. This meta-analysis resulted in a weak but statistically significant association between genital use of talc and ovarian cancer, which appears to be limited to serous carcinoma with suggestion of dose-response. The heterogeneity of results by study design however, detracts from a causal interpretation of this association. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.