Research Papers: Gastrointestinal CancerAn explanatory and predictive model of the variation in esophageal cancer incidence on the basis of changes in the exposure to risk factorsCastro, Claraa,b,c; Peleteiro, Bárbarab,c; Morais, Samanthab; Severo, Miltonb,c; Bento, Maria Joséa; Lunet, Nunob,c Author Information aNorth Region Cancer Registry (RORENO), Department of Epidemiology, Portuguese Oncology Institute of Porto bEPIUnit – Institute of Public Health, University of Porto cDepartment of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal Correspondence to Clara Castro, MSc, North Region Cancer Registry of Portugal (RORENO), Department of Epidemiology, Portuguese Oncology Institute of Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal Tel: +351 22 5084067; fax: +351 22 5084004;e-mail: [email protected] European Journal of Cancer Prevention: May 2018 - Volume 27 - Issue 3 - p 213-220 doi: 10.1097/CEJ.0000000000000422 Buy SDC Metrics Abstract Variations in the exposure to risk factors may be used to explain past cancer trends and to predict its future burden. This study aimed to develop a model to describe and predict the variation of esophageal cancer incidence in 1995–2005, taking into account changes in exposures to risk factors. We adapted an existing model to calculate the expected variation in the number of esophageal cancer cases, between 1995 and 2005, in Australia, Japan, Italy, Portugal, the UK, and the USA, because of changes in exposures to risk factors, taking into account the corresponding lag times. Analyses were based on country-specific data of cancer incidence and exposures to risk factors. We computed 95% credibility intervals through Monte Carlo simulation methods. Absolute deviations between the number of cases predicted and those observed in 2005 ranged between 1.8% in Japan and 23.6% in the UK among men and 0.0% in Japan and 18.0% in Australia among women. In Italy and Japan, deviations did not exceed 3%. The UK registered the worst model performance. The variation in esophageal cancer incidence was mainly influenced by changes in fruit and red meat intake, and BMI. For nearly half of the sex-specific and histological type-specific predictions performed, credibility intervals included the observed number of cases. This study proposes a framework for the analysis of the contribution of changes in exposure to different factors to esophageal cancer incidence trends and for long-term predictions at a population level. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.