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Coffee consumption and risk of nonmelanoma skin cancer

a dose–response meta-analysis

Vaseghi, Golnaza; Haghjoo-Javanmard, Shaghayeghb,c; Naderi, Jamalb; Eshraghi, Azadehe; Mahdavi, Manijehb; Mansourian, Marjanb,d

European Journal of Cancer Prevention: March 2018 - Volume 27 - Issue 2 - p 164–170
doi: 10.1097/CEJ.0000000000000322
Review Article: Skin Cancer

Several epidemiological studies have evaluated the associations between coffee consumption and the risk of skin cancer; however, the results were not conclusive. This systematic review and meta-analysis of the cohort and case–control studies was carried out to determine the association between coffee intake and the risk of nonmelanoma skin cancer. Studies were identified by searching the PubMed and MEDLINE databases (to November 2015). Study-specific risk estimates were pooled under the random-effects model. We separately estimated the relative risk of the three conditions, for exposure to different doses of coffee consumption, kind of study design, and analysis restricted to the basal cell carcinoma type. The summary relative risks for nonmelanoma skin cancer were 0.96 [95% confidence interval (CI): 0.92–0.99] for one cup of coffee, 0.92 (95% CI: 0.88–0.97) for one to two cups of coffee, 0.89 (95% CI: 0.86–0.93) for two to three cups of coffee, and 0.81 (95% CI: 0.77–0.85) for more than three cups of coffee per day, respectively. This meta-analysis suggested that caffeinated coffee might have chemopreventive effects against basal cell carcinoma dose dependently. However, other prospective studies are warranted to confirm these effects.

aIsfahan Cardiovascular Research Center

bApplied Physiology Research Center, Cardiovascular Research Institute

cDepartment of Physiology, School of Medicine

dDepartment of Biostatic and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan

eDepartment of Clinical Pharmacy, Faculty of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran

Correspondence to Marjan Mansourian, PhD, Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, HezarJerib St., 81745 Isfahan, Iran Tel: +98 313 7922651; fax: +98 313 7922800; e-mail:

Received May 1, 2016

Accepted October 15, 2016

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