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Trends in net survival from colon cancer in six European Latin countries

results from the SUDCAN population-based study

Faivre, Jean; Bossard, Nadine; Jooste, Valérie the GRELL EUROCARE-5 Working Group

European Journal of Cancer Prevention: January 2017 - Volume 26 - Issue - p S40–S47
doi: 10.1097/CEJ.0000000000000293
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Colon cancer represents a major public health issue. The aim of the SUDCAN collaborative study was to compare the net survival from colon cancer between six European Latin countries (Belgium, France, Italy, Portugal, Spain, and Switzerland) and provide trends in net survival and dynamics of the excess mortality rates up to 5 years after diagnosis. The data were extracted from the EUROCARE-5 database. First, net survival was studied over the 2000–2004 period using the Pohar-Perme estimator. For trend analyses, the study period was specific to each country. Results were reported from 1992 to 2004 in France, Italy, Spain, and Switzerland and from 2000 to 2004 in Belgium and Portugal. These analyses were carried out using a flexible excess rate modeling strategy. There were few differences between countries in age-standardized net survivals (2000–2004). During the 2000–2004 period, the 5-year net survival ranged between 57 (Spain and Portugal) and 61% (Belgium and Switzerland). The age-standardized survival at 1 and 5 years after diagnosis increased between 1992 and 2004. This increase was observed at ages 60 and 70, but was less marked at 80. This increase was linked to a marked decrease in the excess mortality rate between 1992 and 2004 until 18 months after diagnosis. Beyond this period, the decrease in the excess mortality rates among countries was modest and nearly the same whatever the year of diagnosis. There were minor differences in survival after colon cancer between European Latin countries. A considerable improvement in the 5-year net survival was observed in all countries, but the gain was mainly limited to the first 18 months after diagnosis. Further improvements are expected through the implementation of mass screening programs.

aDigestive cancer registry of Burgundy F-21079, INSERM U866, CHU Dijon, University of Burgundy

bDepartment of Biostatistics, University Hospital of Lyon

cUniversity of Lyon, Lyon

dUniversity of Lyon 1, Lyon

eCNRS, UMR5558, Biometry and Evolutionary Biology laboratory (LBBE), BioMaths-Health Department, Villeurbanne, France

* List of the members available at http://links.lww.com/EJCP/A137

Correspondence to Jean Faivre, Pr, Registre Bourguignon des Cancers Digestifs, INSERM U866, Faculté de Médecine, BP 87900, F-21079 Dijon Cedex, France Tel: +33 3 80 39 33 40; fax: +33 3 80 66 82 51; e-mail: jean.faivre@u-bourgogne.fr

Received April 25, 2016

Accepted June 3, 2016

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