Review Articles: LifestyleGanoderma: insights into anticancer effectsKladar, Nebojša V.; Gavarić, Neda S.; Božin, Biljana N.Author Information Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia Correspondence to Nebojša V. Kladar, MSc, Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia Tel/fax: +381 21 422 760; e-mail: [email protected] European Journal of Cancer Prevention: September 2016 - Volume 25 - Issue 5 - p 462-471 doi: 10.1097/CEJ.0000000000000204 Buy Metrics Abstract The genus Ganoderma includes about 80 species growing on cut or rotten trees. The most commonly used species is Ganoderma ludicum. Biomolecules responsible for the health benefits of Ganoderma are polysaccharides with an immunostimulative effect and triterpenes with a cytotoxic action. For more than 2000 years, it has been used traditionally in the treatment of various pathological conditions and recently, its immunoregulatory, antiviral, antibacterial, antioxidant, hepatoprotective, and anticancer potential has been confirmed. A wide range of Ganoderma extracts and preparations arrest the cell cycle in different phases and consequently inhibit the growth of various types of cancer cells. Extracts containing polysaccharides stimulate immunological reactions through the production of various cytokines and mobilization of immune system cells. In-vivo studies have confirmed the anticancer potential and the antimetastatic effects of compounds originating from Ganoderma. There is also evidence for the chemopreventive action of Ganoderma extracts in bladder, prostate, liver, and breast cancer. The results of clinical studies suggest the combined use of G. lucidum with conventional chemotherapy/radiotherapy, but the methodology and the results of these studies are being questioned. Therefore, a constant need for new clinical trials exists. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.