Review Article: Gastrointestinal CancerThe association between BMI and cervical cancer risk a meta-analysisPoorolajal, Jalal; Jenabi, EnsiyehAuthor Information aDepartment of Epidemiology & Biostatistics, Modeling of Noncommunicable Diseases Research Center, School of Public Health, Hamadan University of Medical Sciences bDepartment of Midwifery, Toyserkan Branch, Islamic Azad University, Toyserkan, Iran Correspondence to Ensiyeh Jenabi, MSc, Department of Midwifery, Toyserkan Branch, Islamic Azad University, Toyserkan, Hamadan 6517838695, Iran Tel: +98 81 34926634; fax: +98 81 34925353; e-mail: [email protected] Received January 22, 2015 Accepted March 27, 2015 European Journal of Cancer Prevention: May 2016 - Volume 25 - Issue 3 - p 232-238 doi: 10.1097/CEJ.0000000000000164 Buy Metrics Abstract The association between BMI and cervical cancer risk is not clear. This meta-analysis was carried out to estimate the association between overweight and obesity and cervical cancer risk. We searched PubMed, Web of Science, Scopus, ScienceDirect, LILACS, and SciELO for observational studies addressing the association between BMI and cervical cancer until February 2015. Data were independently extracted and analyzed using odds ratios and 95% confidence intervals (CIs), on the basis of random-effects models. We identified a total of 3543 references and included nine studies with 128 233 participants. On the basis of the results of case–control and cohort studies, the association between cervical cancer and overweight was estimated to be 1.03 (95% CI: 0.81, 1.25) and 1.10 (95% CI: 1.03, 1.17), respectively. According to the results of case–control and cohort studies, the association between cervical cancer and obesity was estimated to be 1.40 (95% CI: 1.08, 1.71) and 1.08 (95% CI: 0.60, 1.52), respectively. No evidence of heterogeneity and publication bias was observed. The findings from this meta-analysis indicate that overweight is not associated with an increased risk of cervical cancer, but obesity is weakly associated with an increased risk of cervical cancer. However, more evidence, based on large prospective cohort studies, is required to provide conclusive evidence on whether or not BMI is associated with an increased risk of cervical cancer. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.