Review Article: CarcinogenesisMolecular targets of luteolin in cancerTuorkey, Muobarak J.Author Information Zoology Department, Division of Physiology, Faculty of Science, Damanhour University, Damanhour, Egypt Correspondence to Muobarak J. Tuorkey, PhD, Zoology Department, Faculty of Science, Damanhour University, 14 El-Gomhoria Street, Damanhour, Al-Behira 22111, Egypt Tel: +20 198 624 037; fax: +20 453 368 757; e-mail: [email protected] Received August 4, 2014 Accepted December 23, 2014 European Journal of Cancer Prevention: January 2016 - Volume 25 - Issue 1 - p 65-76 doi: 10.1097/CEJ.0000000000000128 Buy Metrics Abstract Many food-derived phytochemical compounds and their derivatives represent a cornucopia of new anticancer compounds. Despite extensive study of luteolin, the literature has no information on the exact mechanisms or molecular targets through which it deters cancer progression. This review discusses existing data on luteolin’s anticancer activities and then offers possible explanations for and molecular targets of its cancer-preventive action. Luteolin prevents tumor development largely by inactivating several signals and transcription pathways essential for cancer cells. This review also offers insights into the molecular mechanisms and targets through which luteolin either prevents cancer or mediates cancer cell death. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.