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Theories of cancer origin

Paduch, Roman

European Journal of Cancer Prevention: January 2015 - Volume 24 - Issue 1 - p 57–67
doi: 10.1097/CEJ.0000000000000024
Review Article: Carcinogenesis

Throughout centuries, many theories have been proposed to explain the origin of cancer. In this review, some of them are presented and briefly commented upon. The theories discussed are divided into epigenetic and genetic ones, with the latter further classified into gene-based and genome-based hypotheses. Multistage cancer development leading to the mutator, malignant cell phenotype is also described. Finally, the current hot topic of cancer stem cells is presented.

Department of Virology and Immunology, Institute of Microbiology and Biotechnology, Maria Curie-Skłodowska University, Lublin, Poland

Correspondence to Roman Paduch, PhD, Department of Virology and Immunology, Institute of Microbiology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, Poland Tel: +48 81 537 59 44; fax: +48 81 537 59 59; e-mail: rpaduch@poczta.umcs.lublin.pl

Received December 17, 2013

Accepted February 28, 2014

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