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DUSP10 gene polymorphism and risk of colorectal cancer in the Han Chinese population

Zhang, Taoa,*; Li, Xiaolanb,*; Du, Qingguoa; Gong, Sangmingjiua; Wu, Mina; Mao, Zhijuna; Gao, Zengzhana; Long, Yanbina; Jin, Tianbob,c; Geng, Tingtingc; Wang, Jianhuaa; Chen, Chaob,c

European Journal of Cancer Prevention: May 2014 - Volume 23 - Issue 3 - p 173–176
doi: 10.1097/CEJ.0b013e3283647408
Research Papers: Colorectal Cancer

Dual-specificity protein phosphatases (DUSP) negatively regulate members of the mitogen-activated protein kinase superfamily, which is associated with cellular proliferation and differentiation. A recent study suggests that DUSP10 is frequently upregulated in colorectal cancer (CRC). Our study aimed to assess whether DUSP10 contributes to the risk of CRC. We analyzed nine tag single nucleotide polymorphisms (tSNPs) of DUSP10 in a case–control study of Han Chinese by the χ 2-test and the SHEsis software. We found that two tSNPs (rs908858, P=0.00004; rs11118838, P=0.02510) were significantly associated with CRC using the χ 2-test. Using the SHEsis software, six tSNPs (rs12041033, rs17010629, rs12724393, rs12036163, rs11118838, rs12044821) were found in the same linkage disequilibrium block. Within this linkage disequilibrium block, haplotype ‘CTCAAC’ showed an increased risk of CRC by 42%. By global haplotype analysis, we found that the haplotype ‘ACTCAACTA’ may increase the risk of CRC by ∼53%; the haplotype ‘GCCCACCCA’ may decrease the risk by ∼46%. Our results, combined with previous studies, suggest that certain mutations in DUSP10 correlate with the incidence of CRC. Thus, the function of the DUSP10 gene product may contribute toward CRC in the Han Chinese population.

aSecond Department of General Surgery, Shaanxi Province Hospital

bSchool of Life Sciences, Northwest University

cNational Engineering Research Center for Miniaturized Detection Systems, Xi’an, China

* Tao Zhang and Xiaolan Li: Joint first authors.

Correspondence to Jianhua Wang, MD, Second Department of General Surgery, Shaanxi Province Hospital, 710068 Xi’an, China Tel: +86 29 85251331; fax: +86 29 85236987;e-mail:

Received March 10, 2013

Accepted May 31, 2013

© 2014 Lippincott Williams & Wilkins, Inc.