Review Article: Gastrointestinal CancerBody mass index, physical activity, and colorectal cancer by anatomical subsites a systematic review and meta-analysis of cohort studiesRobsahm, Trude E.a; Aagnes, Bjartea; Hjartåker, Anetteb; Langseth, Hildea; Bray, Freddie I.c; Larsen, Inger K.a Author Information aThe Cancer Registry of Norway, Institute of Population-Based Cancer Research bDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway cInternational Agency for Research on Cancer, Section of Cancer Information, Lyon, France Correspondence to Trude E. Robsahm, PhD, The Cancer Registry of Norway, Institute of Population-Based Cancer Research, PO Box 5313, Majorstuen, 0304 Oslo, Norway Tel: +47 23 33 39 32/+47 22 45 13 00; fax: +47 22 45 13 70; e-mail: [email protected] Received October 4, 2012 Accepted February 26, 2013 European Journal of Cancer Prevention 22(6):p 492-505, November 2013. | DOI: 10.1097/CEJ.0b013e328360f434 Buy Metrics Abstract Several studies report varying incidence rates of cancer in subsites of the colorectum, as an increasing proportion appears to develop in the proximal colon. Varying incidence trends together with biological differences between the colorectal segments raise questions of whether lifestyle factors impact on the risk of cancer differently at colorectal subsites. We provide an updated overview of the risk of cancer at different colorectal subsites (proximal colon, distal colon, and rectum) according to BMI and physical activity to shed light on this issue. Cohort studies of colorectal cancer, published in English throughout 2010, were identified using PubMed. The risk estimates from 30 eligible studies were summarized for BMI and physical activity. A positive relationship was found between BMI and cancer for all colorectal subsites, but most pronounced for the distal colon [relative risk (RR) 1.59, 95% confidence interval (CI) 1.34–1.89]. For the proximal colon and rectum, the risk estimates were 1.24 (95% CI 1.08–1.42) and 1.23 (95% CI 1.02–1.48), respectively. Physical activity was related inversely to the risk of cancer at the proximal (RR 0.76, 95% CI 0.70-0.83) and distal colon (RR 0.77, 95% CI 0.71–0.83). Such a relationship could not be established for the rectum (RR 0.98, 95% CI 0.88–1.08). In conclusion, the results suggest minor differences in the associations of BMI and the risk of cancer between the colorectal subsites. For physical activity, the association does not seem to differ between the colonic subsites, but a difference was observed between the colon and the rectum, perhaps indicating that different mechanisms are operating in the development of colon and rectal cancer. © 2013 Lippincott Williams & Wilkins, Inc.