Research Papers: Gastrointestinal CancerHepatitis B virus status and the risk of pancreatic cancer a meta-analysisWang, Yunxiaa,*; Yang, Shenglic,*; Song, Fujiand; Cao, Shiyia; Yin, Xiaoxva; Xie, Juna; Tu, Xiaochena; Xu, Jingb; Xu, Xinga; Dong, Xiaoxina; Lu, ZuxunaAuthor Information aDepartment of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan bDepartment of Public Management, The Humanities School, Henan University of Traditional Chinese Medicine, Zhengzhou, People’s Republic of China cDepartment of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong dNorwich Medical School, Faculty of Medicine and Health Science, University of East Anglia, Norwich, UK *Yunxia Wang and Shengli Yang contributed equally to the writing of this article. Correspondence to Zuxun Lu, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China Tel/fax: +86 27 83693756; e-mail: [email protected] Received August 9, 2012 Accepted September 9, 2012 European Journal of Cancer Prevention: July 2013 - Volume 22 - Issue 4 - p 328-334 doi: 10.1097/CEJ.0b013e32835b6a21 Buy Metrics Abstract Objective Whether hepatitis B virus (HBV) infection increases the risk of pancreatic cancer (PaC) is controversial. We carried out a meta-analysis to evaluate the association between HBV status and the risk of PaC. Methods PubMed, Embase, and the China National Knowledge Infrastructure were searched from their inception through April 2012 for case–control and cohort studies that have reported an association between HBV status and the risk of PaC. The reference lists of pertinent publications were also reviewed for potential studies. Methodological quality was assessed using the Newcastle–Ottawa Quality Assessment Scale. A random-effects model was used to summarize odd ratios (ORs) and 95% confidence intervals (CIs). Results We included seven case–control studies and three cohort studies, involving 5883 PaC cases. The summary OR of developing PaC was 1.22 (95% CI: 0.90–1.67) for individuals who were HBV surface antigen (HBsAg)-positive. Compared with the individuals who were never exposed to HBV infection, the summary OR of the risk of PaC was 1.60 (95% CI: 1.26–2.05) for chronic or inactive HBsAg carriers (HBsAg-positive) and 1.76 (95% CI: 1.05–2.93) for anti-HBc-positive but anti-HBs-negative individuals. Conclusion Inactive HBsAg carrier status and possible occult HBV infection may increase the risk of PaC. Large population-based multicenter prospective studies are required to further confirm this finding. © 2013 Lippincott Williams & Wilkins, Inc.