Research Papers: Gastrointestinal CancerHigh incidence of esophageal cancer in central-western Brazil a migrant effect?Silva, Diego Rodrigues Mendonça ea,b; Curado, Maria-Paulab,c; de Oliveira, José Carlosb Author Information aGraduate Program in Health Sciences, Federal University of Goias bPopulation-Based Cancer Registry of Goiania, Association of Cancer Combat of Goias, Goiania, Brazil cInternational Prevention Research Institute (IPRI), Lyon, France Correspondence to Maria-Paula Curado, PhD, MD, International Prevention Research Institute (IPRI), 15, Chemin du Saquin, Espace Européen, 69130 Lyon, France Tel: +33 04 72 17 11 92; fax: +33 04 72 17 11 90; e-mail: [email protected] Received April 26, 2012 Accepted July 30, 2012 European Journal of Cancer Prevention: May 2013 - Volume 22 - Issue 3 - p 235-243 doi: 10.1097/CEJ.0b013e3283592c9d Buy Metrics Abstract To determine the incidence and mortality rates of esophageal cancer in central-western Brazil: Goiânia, Brasília, Cuiabá, and Campo Grande, incidence data for Cuiabá (2000–2005) and Brasília (1999–2002) were obtained from the National Cancer Institute, and data from Goiânia (1995–2008) from the Population-Based Cancer Registry of Goiânia. Mortality data for the cities of central-western Brazil were obtained for the period 1980–2008 from the Ministry of Health. Age-standardized incidence and mortality rates were calculated using the world population of Segi. Mortality trends were assessed with the Joinpoint Regression Program and a P value less than 0.05 was defined as significant. The highest incidence of esophageal cancer among men was in Cuiabá (16.0/100 000); the lowest was in Goiânia (6.5/100 000). Among women, the incidence rates were similar in Brasília and Cuiabá, but in Goiânia, the incidence declined. There was a significant increase in mortality among men in Cuiabá (2.4%, P=0.03) and Campo Grande (1.2%, P=0.05), and in women (1.6%, P=0.04) in Goiânia. Mortality by age group increased significantly in Campo Grande by 1.9% for men aged at least 50 years and in Goiânia by 2.7% among women aged at least 50 years; the mortality decreased in Goiânia by 2.2% for women aged less than 50 years. The incidence of esophageal cancer in Brasília and Cuiabá was similar to that of southern Brazil in some periods. There was an increase in mortality trends for men in Cuiabá and Campo Grande, and for women in Goiânia. © 2013 Lippincott Williams & Wilkins, Inc.