Research Papers: Breast CancerSerum cholesterol level, use of a cholesterol-lowering drug, and breast cancer: results from the prospective E3N cohortFagherazzi, Guy; Fabre, Alban; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, FrançoiseAuthor Information Institut National de la Santé et de la Recherche Médicale, ERI-20, EA4045 Paris-Sud Université, and Institut Gustave Roussy, Villejuif, France Correspondence to Dr Françoise Clavel-Chapelon, PhD, Institut National de la Santé et de la Recherche Médicale, Espace Maurice Tubiana, 39 rue Camille Desmoulins, 94805 Villejuif, Cedex, France Tel: +33 1 42 11 41 48; fax: +33 1 42 11 40 00; e-mail: email@example.com Received 7 September 2009 Accepted 8 October 2009 European Journal of Cancer Prevention: March 2010 - Volume 19 - Issue 2 - p 120-125 doi: 10.1097/CEJ.0b013e3283354918 Buy Metrics Abstract Metabolic syndrome, including low HDL cholesterol, has been associated with an increased breast cancer risk, whereas little is known of the relationship with total cholesterol. Cox proportional hazards regression models were performed to evaluate the association between self-reported total serum cholesterol, cholesterol-lowering drugs, and risk of breast cancer in 69 088 women from the French E3N cohort study. A total of 2932 cases of primary invasive breast cancer were reported during 12 years of follow-up. Compared with women with low/normal serum cholesterol (<6.6 mol/l), users of cholesterol-lowering drugs had a significantly decreased breast cancer risk [hazard ratio (HR): 0.79, 95% confidence interval (CI): 0.68, 0.93]. There was no variation in HRs according to the menopausal status. In strata defined by the hormone receptor status of the tumor, the risk reached statistical significance only for the estrogen-positive and progesterone-positive receptor subtype (HR: 0.64, 95% CI: 0.50, 0.82). A high cholesterol without cholesterol-lowering drug use was not associated with breast cancer risk (HR: 0.99, 95% CI: 0.85, 1.15) in the entire population. Our result concerning cholesterol-lowering drugs is consistent with studies showing that hypolipidemic molecules are effective in inhibiting cancer cell growth proliferation. Further studies should investigate whether these findings apply to all classes of cholesterol-lowering drugs. © 2010 Lippincott Williams & Wilkins, Inc.