Research Papers: Breast CancerDecreasing trend of tumor size and downstaging in breast cancer in Iran: results of a 15-year studyHarirchi, Iraja; Karbakhsh, Mojganb; Montazeri, Alic; Ebrahimi, Mandanad; Jarvandi, Soghrad; Zamani, Nedad; Momtahen, Amir-Javada; Kashefi, Amira; Zafarghandi, Mohammad-RezaeAuthor Information aCancer Institute, Cancer Research Center bDepartment of Community Medicine, Tehran University of Medical Sciences cIranian Institute for Health Sciences Research (IHSR), Tehran dIranian Centre for Breast Cancer (ICBC), Tehran eSurgery Department, Sina Hospital Tehran University of Medical Sciences Correspondence to Iraj Harirchi, MD, Tehran University of Medical Sciences, Qods Street, Enghelab Avenue, Tehran 1417863181, Iran Tel: +98 21 66491070; fax: +98 21 66419537; e-mail: email@example.com Received 5 May 2009 Accepted 4 September 2009 European Journal of Cancer Prevention: March 2010 - Volume 19 - Issue 2 - p 126-130 doi: 10.1097/CEJ.0b013e328333d0b3 Buy Metrics Abstract The aim of this cross-sectional study was to show the characteristics of breast cancer across a period of 15 years according to pathological records in Tehran, Iran. In the year 1985, a 20-year study was designed and developed in five major hospitals in Tehran to study the burden and characteristics of breast cancer in Iran. This study is based on the data collected from 1986 through 2000. SPSS version 13 was used for statistical analysis. In this study, 1612 female breast cancer records were reviewed. The mean age of patients was 47.95±12.42 years with a median of 47 years. Over the study period, the proportion of tumors diagnosed at T2 increased with a decline in the proportion of T3 cases. Similarly, the percentage of stage II cases at diagnosis increased, whereas stage III decreased. We detected a decrease in tumor size and downstaging of female breast cancer in Tehran, Iran. This can be attributed to the overall improvement in the level of health in Iran and also educational activities that teach women how to perform breast self-exam and when and why to ask for breast examination. © 2010 Lippincott Williams & Wilkins, Inc.