Research Papers: Gastrointestinal CancerIs temperature an effect modifier of the association between green tea intake and gastric cancer risk?Deandrea, Silviaa b; Foschi, Robertoa; Galeone, Carlottaa b; La Vecchia, Carloa b; Negri, Evaa; Hu, Jinfuc d Author Information aIstituto di Ricerche Farmacologiche ‘Mario Negri’ bIstituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milano, Italy cEvidence and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada dDepartment of Epidemiology, Harbin Medical University, Harbin, China Correspondence to Carlo La Vecchia, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Giuseppe La Masa 19, 20156 Milan, Italy Tel: +39 02 3901 4527; fax: +39 02 3320 0231; e-mail: [email protected] Received 20 April 2009 Accepted 16 July 2009 European Journal of Cancer Prevention: January 2010 - Volume 19 - Issue 1 - p 18-22 doi: 10.1097/CEJ.0b013e328330eb1a Buy Metrics Abstract We considered the relationship between green tea and gastric cancer risk in Harbin, Heilongjiang province, Northeast China, an area with high baseline risk of stomach cancer. We used data from a case–control study conducted from 1987 to 1989 among 266 incident cases of stomach cancer and 533 controls admitted to the same hospitals as cases, with non-neoplastic and non-gastric diseases. No association emerged when tea consumption alone was considered: the odds ratio (OR) for green tea consumption was 0.87 (95% CI: 0.60–1.25) for green tea intake ≥750 g/year versus no intake and 0.99 (95% CI: 0.97–1.02) for an increment of 500 g of tea per year. When tea consumption was classified according to the temperature, however, the OR was 0.19 (95% CI: 0.07–0.49) for lukewarm tea intake ≥750 g/year and 1.27 (95% CI: 0.85–1.90) for hot tea intake (P value for interaction <0.001) as compared with non-drinkers. The corresponding ORs for an increment of 500 g of tea per year were 0.61 (95% CI: 0.45–0.82) and 1.03 (95% CI: 0.99–1.07) for lukewarm and hot tea, respectively (P value for interaction <0.001). We found an inverse relationship between green tea drinking and gastric cancer risk limited to the intake of lukewarm tea. © 2010 Lippincott Williams & Wilkins, Inc.