Research papers: Gynecological CancerFamily history of cancer and the risk of endometrial cancerLucenteforte, Ersiliaa; Talamini, Renatoc; Montella, Mauriziod; Maso, Luigino Dalc; Pelucchi, Claudioa; Franceschi, Silviae; La Vecchia, Carloa b; Negri, Evaa Author Information aMario Negri Institute for Pharmacological Research, Milan bInstitute of Medical Statistics “G.A. Maccacaro”, University of Milan, Milan cEpidemiology and Biostatistics Unit, Oncologic Referral Centre, Aviano dEpidemiology Unit, National Cancer Institute ‘Fondazione Giovanni Pascale’, Naples, Italy eInternational Agency for Research on Cancer, Lyon Cedex, France Correspondence to Dr Ersilia Lucenteforte, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Giuseppe La Masa 19-20156 Milan, Italy Tel: +39 023 901 4652; fax: +39 023 320 0231; e-mail: [email protected] Received 20 November 2007 Accepted 20 March 2008 European Journal of Cancer Prevention: April 2009 - Volume 18 - Issue 2 - p 95-99 doi: 10.1097/CEJ.0b013e328305a0c9 Buy Metrics Abstract To investigate the relationship between family history of cancer in first-degree relatives and the risk of endometrial cancer, we carried out a large multicentre case–control study in Italy between 1992 and 2006, including 454 endometrial cancer cases and 908 controls admitted in hospital for acute, non-neoplastic diseases. Conditional logistic regression was used to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CI). Relative to women with no family history of uterine cancer, the ORs were 2.1 (95% CI: 0.7–6.4) for those reporting a family history of endometrial cancer and 1.8 (95% CI: 1.0–3.2) for a family history of any uterine cancer. A family history of intestinal cancer was directly associated with endometrial cancer risk (OR=1.6; 95% CI: 1.0–2.7). Direct associations were found for a few other cancer sites. In conclusion, a family history of endometrial, uterine or intestinal cancer in first-degree relatives is associated with an increased risk of endometrial cancer. © 2009 Lippincott Williams & Wilkins, Inc.