Research papers: Other CancersType of alcoholic beverage and the risk of laryngeal cancerGaravello, Wernera b; Bosetti, Cristinaa; Gallus, Silvanoa; Maso, Luigino Dalc; Negri, Evaa; Franceschi, Silviad; Vecchia, Carlo Laa eAuthor Information aIstituto di Ricerche Farmacologiche “Mario Negri”, Milan bClinica Otorinolaringoiatrica, DNTB, Universita` Milano-Bicocca, Monza cServizio di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano (PN), Italy dInternational Agency for Research on Cancer, Lyon, France eIstituto di Statistica Medica e Biometria, Universita` degli Studi di Milano, Italy Correspondence to Dr Cristina Bosetti, Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea 62, 20157 Milan, Italy Tel: +0039 02 39014526; fax: +0039 02 33200231; e-mail: [email protected] Received 13 February 2005 Accepted 9 June 2005 European Journal of Cancer Prevention: February 2006 - Volume 15 - Issue 1 - p 69-73 doi: 10.1097/01.cej.0000186641.19872.04 Buy Metrics Abstract A few studies have investigated whether the risk of laryngeal cancer depends on the types of alcoholic beverage consumed, providing conflicting results. We investigated this issue using the data from two case–control studies conducted in Italy between 1986 and 2000. These included 672 cases of laryngeal cancer and 3454 hospital controls, admitted for acute, non-neoplastic conditions, unrelated to smoking and alcohol consumption. Significant trends in risk were found for total alcohol intake, with multivariate odds ratios (ORs) of 1.12 for drinkers of 3–4 drinks/day, 2.43 for 5–7, 3.65 for 8–11, and 4.83 for > 12 drinks/day, as compared to abstainers or light drinkers. Corresponding ORs for wine drinkers were 1.12, 2.45, 3.29 and 5.91. After allowance was made for wine intake, the ORs for beer drinkers were 1.65 for 1–2 drinks/day, and 1.36 for ≥ 3 drinks/day, as compared to non-beer drinkers; corresponding values for spirits drinkers were 0.88 and 1.15. This study thus indicates that in the Italian population characterized by frequent wine consumption, wine is the beverage most strongly related to the risk of laryngeal cancer. © 2006 Lippincott Williams & Wilkins, Inc.