Aspirin and the risk of prostate cancer : European Journal of Cancer Prevention

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Research papers: Prostate Cancer

Aspirin and the risk of prostate cancer

Bosetti, Cristinaa; Talamini, Renatob; Negri, Evaa; Franceschi, Silviac; Montella, Mauriziod; La Vecchia, Carloa e

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European Journal of Cancer Prevention 15(1):p 43-45, February 2006. | DOI: 10.1097/


Epidemiological studies have suggested that aspirin may have a protective effect against prostate cancer, but the evidence is still limited and inconsistent. The role of aspirin in prostate cancer risk was analysed in a multicentric case–control study conducted in Italy between 1991 and 2002, including 1261 incident cases of carcinoma of the prostate and 1131 hospital controls. A total of 115 (9.1%) cases versus 90 (8.0%) controls reported regular aspirin use. The multivariate odds ratio (OR) for regular aspirin users was 1.10 (95% confidence interval (95% CI) 0.81–1.50). No relation was found with duration of use (OR=1.03 for <5 years, and 1.17 for ≥5 years) and time since first use (OR=1.03 for <10 years, and 1.35 for ≥10 years). These findings do not support a protective role of regular aspirin use on prostate cancer risk.

© 2006 Lippincott Williams & Wilkins, Inc.

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