Michael J Hill Memorial LectureMediterranean diet, antioxidants and cancer: the need for randomized trialsMartinez-Gonzalez, M A1; Estruch, R2Author Information 1Department of Epidemiology and Public Health, School of Medicine, University of Navarra, Spain 2Department of Internal Medicine, Hospital Clinic, Barcelona, Spain Correspondence to: M A Martinez-Gonzalez. Fax: (+34) 948 425649. E-mail: email@example.com European Journal of Cancer Prevention: August 2004 - Volume 13 - Issue 4 - p 327-335 doi: 10.1097/01.cej.0000137512.71845.bf Buy Metrics Abstract In nutritional epidemiology the traditional approach has been to assess single nutrients or food items. Now, a growing interest exists in dietary patterns. The study of dietary patterns with a whole-diet approach represents a needed and complementary methodology. Among a priori defined patterns, the highly palatable traditional Mediterranean diet has many options to be the first choice in the dietary prevention of cancer. However, sound epidemiologic evidence about its ability to prevent the most frequent cancers is scarce. In conjunction with large and well-designed cohort studies, randomized trials using a whole-diet approach and not a simple antioxidant supplement are needed in Mediterranean countries. © 2004 Lippincott Williams & Wilkins, Inc.