Research papersAllergy and the risk of selected digestive and laryngeal neoplasmsBosetti, C1; Talamini, R2; Franceschi, S3; Negri, E1; Giacosa, A4; Vecchia, C La1 5Author Information 1Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea 62, 20157 Milan 2Servizio di Epidemiologia e Bistatistica, Centro di Riferimento Oncologico, Aviano (PN), Italy 3International Agency for Research on Cancer, Lyon, France 4Istituto Nazionale per la Ricerca sul Cancro, Genoa 5Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy Correspondence to: C Bosetti. Fax: (+39) 02 3320 0231 E-mail: [email protected] Received 21 July 2003 Accepted 6 February 2004 European Journal of Cancer Prevention: June 2004 - Volume 13 - Issue 3 - p 173-176 doi: 10.1097/01.cej.0000130016.85687.cf Buy Metrics Abstract The relation between allergy and cancer has been investigated within an integrated series of case–control studies of digestive tract and laryngeal neoplasms conducted in Italy since the early 1990s. These included 598 patients with incident, histologically confirmed cancer of the oral cavity and pharynx, 304 of the oesophagus, 1225 of the colon, 728 of the rectum, 460 of the larynx and 4999 controls, selected among patients admitted to the same network of hospitals as cases for acute, non-neoplastic diseases. Inverse associations with history of allergy were found for all cancer sites examined (odds ratio=0.44 for oral cavity and pharynx, 0.80 for oesophagus, 0.76 for colon, 0.54 for rectum and 0.33 for larynx). The associations were consistent in strata of age and sex, and when subjects with a first diagnosis of allergy 5 or more years before cancer diagnosis or hospital admission were considered. The present study therefore provides further evidence for a possible protective effect of prior history of allergy on cancer risk. © 2004 Lippincott Williams & Wilkins, Inc.