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Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions

Ahn, W-S1; Yoo, J2; Huh, S-W3; Kim, C-K4; Lee, J-M1; Namkoong, S-E1; Bae, S-M3; Lee, I P3

European Journal of Cancer Prevention: October 2003 - Volume 12 - Issue 5 - p 383-390
Research papers

We investigated clinical efficacy of green tea extracts (polyphenon E; poly E and (−)-epigallocatechin-3-gallate [EGCG]) delivered in a form of ointment or capsule in patients with human papilloma virus (HPV) infected cervical lesions. Fifty-one patients with cervical lesions (chronic cervicitis, mild dysplasia, moderate dysplasia and severe dysplasia) were divided into four groups, as compared with 39 untreated patients as a control. Poly E ointment was applied locally to 27 patients twice a week. For oral delivery, a 200 mg of poly E or EGCG capsule was taken orally every day for eight to 12 weeks. In the study, 20 out of 27 patients (74%) under poly E ointment therapy showed a response. Six out of eight patients under poly E ointment plus poly E capsule therapy (75%) showed a response, and three out of six patients (50%) under poly E capsule therapy showed a response. Six out of 10 patients (60%) under EGCG capsule therapy showed a response. Overall, a 69% response rate (35/51) was noted for treatment with green tea extracts, as compared with a 10% response rate (4/39) in untreated controls (P<0.05). Thus, the data collected here demonstrated that green tea extracts in a form of ointment and capsule are effective for treating cervical lesions, suggesting that green tea extracts can be a potential therapy regimen for patients with HPV infected cervical lesions.

1Department of Obstetrics and Gynaecology

2Department of Pathology

3Catholic Research Institutes of Medical Science, College of Medicine, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Ku, Seoul 137–040, Korea

4College of Pharmacy, Seoul National University, Shinlim-Dong, Kwanak-Ku, Seoul, 151–742, Korea

Correspondence to W S Ahn. Fax: (+82) 2 599 4120.

E-mail: ahnws@catholic.ac.kr

Received 27 March 2003 Accepted 15 July 2003

© 2003 Lippincott Williams & Wilkins, Inc.