Research papersProtective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesionsAhn, W-S1; Yoo, J2; Huh, S-W3; Kim, C-K4; Lee, J-M1; Namkoong, S-E1; Bae, S-M3; Lee, I P3 Author Information 1Department of Obstetrics and Gynaecology 2Department of Pathology 3Catholic Research Institutes of Medical Science, College of Medicine, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Ku, Seoul 137–040, Korea 4College of Pharmacy, Seoul National University, Shinlim-Dong, Kwanak-Ku, Seoul, 151–742, Korea Correspondence to W S Ahn. Fax: (+82) 2 599 4120. E-mail: [email protected] Received 27 March 2003 Accepted 15 July 2003 European Journal of Cancer Prevention: October 2003 - Volume 12 - Issue 5 - p 383-390 Buy Abstract We investigated clinical efficacy of green tea extracts (polyphenon E; poly E and (−)-epigallocatechin-3-gallate [EGCG]) delivered in a form of ointment or capsule in patients with human papilloma virus (HPV) infected cervical lesions. Fifty-one patients with cervical lesions (chronic cervicitis, mild dysplasia, moderate dysplasia and severe dysplasia) were divided into four groups, as compared with 39 untreated patients as a control. Poly E ointment was applied locally to 27 patients twice a week. For oral delivery, a 200 mg of poly E or EGCG capsule was taken orally every day for eight to 12 weeks. In the study, 20 out of 27 patients (74%) under poly E ointment therapy showed a response. Six out of eight patients under poly E ointment plus poly E capsule therapy (75%) showed a response, and three out of six patients (50%) under poly E capsule therapy showed a response. Six out of 10 patients (60%) under EGCG capsule therapy showed a response. Overall, a 69% response rate (35/51) was noted for treatment with green tea extracts, as compared with a 10% response rate (4/39) in untreated controls (P<0.05). Thus, the data collected here demonstrated that green tea extracts in a form of ointment and capsule are effective for treating cervical lesions, suggesting that green tea extracts can be a potential therapy regimen for patients with HPV infected cervical lesions. © 2003 Lippincott Williams & Wilkins, Inc.