Research papersActive and passive smoking and the risk of stomach cancer, by subsite, in CanadaMao, Y1; Hu, J1; Semenciw, R1; White, K2Canadian Cancer Registries Epidemiology Research GroupAuthor Information 1Surveillance & Risk Assessment, Centre for Chronic Disease Prevention and Control, Population and Public Health Branch, Health Canada, Tunney's Pasture AL0601C1, Ottawa, Ontario K1A 0L2, Canada 2The Canadian Cancer Registries Epidemiology Research Group comprises a Principal Investigator from each of the Provincial Cancer Registries involved in the National Enhanced Cancer Surveillance System: B Paulse, Newfoundland Cancer Foundation; R Dewar, Nova Scotia Cancer Registry; D Dryer, Prince Edward Island Cancer Registry; N Kreiger, Cancer Care Ontario; H Whittaker, Manitoba Cancer Treatment and Research Foundation; D Robson, Saskatchewan Cancer Foundation; S Fincham, Division of Epidemiology, Prevention and Screening, Alberta Cancer Board; N Le, British Columbia Cancer Agency Correspondence to: Y Mao. Fax: (+1) 613 941 2057. E-mail: Yang_Mao@hc-sc.gc.ca Received 9 March 2001 accepted 15 July 2001 European Journal of Cancer Prevention: February 2002 - Volume 11 - Issue 1 - p 27-38 Buy Abstract This study assessed the influence of active and passive smoking on the risk of stomach cancer by subsite. Mailed questionnaires were used to obtain information on 1171 newly diagnosed histologically confirmed stomach cancer cases and 2207 population controls between 1994 and 1997 in eight Canadian provinces. Data were collected on socio-economic status, lifestyle and passive smoking status. Odds ratios (OR) and 95% confidence intervals (95% CI) were derived by logistic regression. Compared with those who had never smoked, there was strongly increased risk for ex- and current smokers among subjects with cardial stomach cancer. For men with cardial cancer, the adjusted ORs were 1.9 (95% CI 1.2–3.0) and 2.6 (95% CI 1.6–4.3) for ex-smokers and current smokers, respectively, with a similar pattern among women. Among men, the adjusted ORs were lower for subsites of stomach cancer other than cardia. These findings suggest that active and passive smoking may play an important role in the development of cardial stomach cancer. © 2002 Lippincott Williams & Wilkins, Inc.