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Origin of ovarian cancer from benign cysts

Dal Maso, L1; Canzonieri, V1; Talamini, R1; Franceschi, S2; La Vecchia, C3,4

European Journal of Cancer Prevention: April 2001 - Volume 10 - Issue 2 - p 197-199
Short Communication

In a case–control study of 1031 epithelial ovarian cancers and 2311 controls conducted in Italy, 56 cases and 116 controls reported history of benign ovarian cysts, corresponding to a relative risk of 1.3 (95% confidence interval = 0.9–1.8). In a subject of 255 histologically reviewed cases, mucinous and endometrioid ovarian neoplasms and neoplasms of stage I or II arose more frequently from cysts, while use of oral contraceptives or parity were not significantly related to history of ovarian cysts.

1Centro di Riferimento Oncologico, Aviano (PN), Italy. 2Field and Intervention Studies Unit, International Agency for Research on Cancer, Lyon Cedex, France. 3Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan, Italy. 4Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy

Correspondence to: C La Vecchia. Laboratory of General Epidemiology, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea 62–20157 Milan, Italy. Fax: (+39) 02 3320 0231. E-mail:

Received 4 December 2000

Accepted 6 January 2001

© 2001 Lippincott Williams & Wilkins, Inc.