Abstracts: ISEE 22nd Annual Conference, Seoul, Korea, 28 August–1 September 2010: Chemicals and Environmental Health Issues (eg, Endocrine Disruptors or Endocrine Disrupting Chemicals)
Mineral Oils and Harmful Effects on Human and Animal Skin
Oil products, such as oils and Vaseline, are widely used not only in industries but also in medical practice. They are components of unguent basis that are used for treatment of various skin diseases.
The dermatotropic effect of oil components was examined by skin test in rabbits. Skin test is an adequate method for the evidence of follicular hyperkeratosis effect of oil products, industrial substances, as well as daily used agents. The examined material was dripped on the upper part of the ear of a rabbit and the amount was 2 drops. After dripping, the ear was caught in a horizontal position until the sample drips evaporated. On the controlled ear, there was control sample applied under the same conditions. Skin test was evaluated by microscopic and macroscopic way.
In the experiment, there was harmfulness of individual sample found as follows:
- The least dermatogenic effect was shown by the hydrocarbons that contain 30.2% of aromatic carbon.
- The higher dermatogenic effect was caused by the sample that contains 35.2% of aromatic carbon.
- The third place was taken by the sample that contains 47.7% of aromatic carbon and caused even bigger dermatogenic effect than the sample N 2.
- The sample with 52.4% of aromatic carbon provoked distinct dermal effect.
- The biggest dermatogenic effect was shown by the sample containing 55.2% of aromatic carbon.
Although carrying experiments on laboratory animals, the harmfulness and possible carcinogen effects of aromatic hydrocarbons on living animals were found out. Having in mind many studies it is advised to use oil products with the least possible percentage of aromatic carbon.
It could contribute a lot to diminishing the distribution of dermatitis among people and animals.
This research is supported by the Agency of Ministry of Education SR for the Structural Funds of the EU, the project: ITMS 26220120023.© 2011 Lippincott Williams & Wilkins, Inc.